• 

  Germline pathogenic variants in PALB2 and other cancer-predisposing genes in families with hereditary diffuse gastric cancer without CDH1 mutation: a whole-exome sequencing study. 

  Fewings, Eleanor; Larionov, Alexey; Redman, James; Goldgraben, Mae A; Scarth, James; Richardson, Susan; Brewer, CaroleDavidson, RosemarieEllis, IanEvans, D GarethHalliday, DorothyIzatt, LouiseMarks, PeterMcConnell, VivienneVerbist, LouisMayes, RebeccaClark, Graeme RHadfield, JamesChin, Suet-FeungTeixeira, Manuel RGiger, Olivier THardwick, Richarddi Pietro, MassimilianoO'Donovan, MariaPharoah, PaulCaldas, CarlosFitzgerald, Rebecca CTischkowitz, Marc et al. (Elsevier BV, 2018-07)

  BACKGROUND: Germline pathogenic variants in the E-cadherin gene (CDH1) are strongly associated with the development of hereditary diffuse gastric cancer. There is a paucity of data to guide risk assessment and management ...
• 

  Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy. 

  Gyori, David; Lim, Ee Lyn; Grant, Francis M; Spensberger, Dominik; Roychoudhuri, Rahul; Shuttleworth, Stephen J; Okkenhaug, KlausStephens, Len RHawkins, Phillip T et al. (American Society for Clinical Investigation, 2018-06-07)

  Redundancy and compensation provide robustness to biological systems but may contribute to therapy resistance. Both tumor-associated macrophages (TAMs) and Foxp3+ regulatory T (Treg) cells promote tumor progression by ...
• 

  Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors. 

  Lim, Ee Lyn; Cugliandolo, Fiorella M; Rosner, Dalya R; Gyori, David; Roychoudhuri, Rahul; Okkenhaug, Klaus (American Society for Clinical Investigation, 2018-06-07)

  Multiple modes of immunosuppression restrain immune function within tumors. We previously reported that phosphoinositide 3-kinase δ (PI3Kδ) inactivation in mice confers resistance to a range of tumor models by disrupting ...
• 

  The VPS4 component of the ESCRT machinery plays an essential role in HPV infectious entry and capsid disassembly. 

  Broniarczyk, Justyna; Pim, David; Massimi, Paola; Bergant, Martina; Goździcka-Józefiak, Anna; Crump, Colin; Banks, Lawrence (Springer Science and Business Media LLC, 2017-03-28)

  Human Papillomavirus (HPV) infection involves multiple steps, from cell attachment, through endocytic trafficking towards the trans-Golgi network, and, ultimately, the entry into the nucleus during mitosis. An essential ...

View more