Scholarly Works - Pathology
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Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy. (2018-06-07)Redundancy and compensation provide robustness to biological systems but may contribute to therapy resistance. Both tumor-associated macrophages (TAMs) and Foxp3+ regulatory T (Treg) cells promote tumor progression by ...
Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors. (2018-06-07)Multiple modes of immunosuppression restrain immune function within tumors. We previously reported that phosphoinositide-3-kinase δ (PI3Kδ) inactivation in mice confers resistance to a range of tumor models by disrupting ...
The VPS4 component of the ESCRT machinery plays an essential role in HPV infectious entry and capsid disassembly. (2017-03-28)Human Papillomavirus (HPV) infection involves multiple steps, from cell attachment, through endocytic tra cking towards the trans-Golgi network, and, ultimately, the entry into the nucleus during mitosis. An essential viral ...