Now showing items 1-20 of 290

• #### A first-generation integrated tammar wallaby map and its use in creating a tammar wallaby first-generation virtual genome map ﻿

(2011-08-19)
Abstract Background The limited (2X) coverage of the tammar wallaby (Macropus eugenii) genome sequence dataset currently presents a challenge for assembly and anchoring onto chromosomes. To provide a framework for this ...
• #### Achieving population-level immunity to rabies in free-roaming dogs in Africa and Asia ﻿

(PLOS, 2014-11-13)
Canine rabies can be effectively controlled by vaccination with readily available, high-quality vaccines. These vaccines should provide protection from challenge in healthy dogs for the claimed period for duration of ...
• #### Actin polymerization as a novel innate immune effector mechanism to control Salmonella infection ﻿

Salmonellosis is one of the leading causes of food poisoning worldwide. Controlling bacterial burden is essential to surviving infection. Nucleotide-binding oligomerization domain-like receptors (NLRs), such as NLRC4, ...
• #### Actinobacillus pleuropneumoniae serovar 8 predominates in England and Wales ﻿

(BMJ Journals, 2016-09-17)
• #### Adaptation of avian influenza virus to a swine host ﻿

(Oxford University Press, 2017-01-31)
The emergence of pathogenic RNA viruses into new hosts can have dramatic consequences for both livestock and public health. Here we characterize the viral genetic changes that were observed in a previous study which ...
• #### alpha-synuclein induced synapse damage is enhanced by amyloid-beta1-42 ﻿

(2010-12-07)
Abstract Background The pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) is associated with the accumulation of aggregated forms of the &#945;-synuclein (&#945;SN) protein. An early event in the ...
• #### Alterations in the vimentin cytoskeleton in response to single impact load in an in vitromodel of cartilage damage in the rat ﻿

(2008-06-24)
Abstract Background Animal models have provided much information on molecular and cellular changes in joint disease, particularly OA. However there are limitations to in vivo work and single tissue in vitro studies can ...
• #### Alternative Molecular Methods for improved detection of meningococcal carriage and measurement of bacterial density ﻿

(American Society for Microbiology, 2016-08-31)
Background: Conventional methods for detecting pharyngeal carriage of Neisseria meningitidis (Nm) are complex. There is a need for simpler methods with improved performance. We have investigated two alternative ...
• #### Analysis of $\textit{Campylobacter jejuni}$ infection in the gnotobiotic piglet and genome-wide ﻿

To investigate how $\textit{Campylobacter jejuni}$ causes the clinical symptoms of diarrhoeal disease in humans, use of a relevant animal model is essential. Such a model should mimic the human disease closely in terms of ...
• #### Analysis of Campylobacter jejuni infection in the gnotobiotic piglet and genome-wide identification of bacterial factors required for infection ﻿

(Nature Publishing Group, 2017-03-10)
To investigate how Campylobacter jejuni causes the clinical symptoms of diarrhoeal disease in humans, use of a relevant animal model is essential. Such a model should mimic the human disease closely in terms of host ...
• #### The Anisakis transcriptome provides a resource for fundamental and applied studies on allergy-causing parasites ﻿

(PLOS, 2016)
Background: Food-borne nematodes of the genus Anisakis are responsible for a wide range of illnesses (= anisakiasis), from self-limiting gastrointestinal forms to severe systemic allergic reactions, which are often ...
• #### Assessing Commitment and Reporting Fidelity to a Text Message-Based Participatory Surveillance in Rural Western Uganda ﻿

(Public Library of Science, 2016-06-09)
Syndromic surveillance, the collection of symptom data from individuals prior to or in the absence of diagnosis, is used throughout the developed world to provide rapid indications of outbreaks and unusual patterns of ...
• #### Assessing the impacts of the first year of rotavirus vaccination in the United Kingdom ﻿

(European Centre for Disease Prevention and Control (ECDC), 2015-12-03)
The United Kingdom (UK) added rotavirus (RV) vaccine (Rotarix GlaxoSmithKline) to the national vaccine schedule in July 2013. During the 2012–2014 rotavirus seasons, children presenting to the Bristol Royal Hospital for ...
• #### Assessing the role of contact tracing in a suspected H7N2 influenza A outbreak in humans in Wales ﻿

(2010-05-28)
Abstract Background The detailed analysis of an outbreak database has been undertaken to examine the role of contact tracing in controlling an outbreak of possible avian influenza in humans. The outbreak, initiating from ...
• #### Assigning and visualizing germline genes in antibody repertoires ﻿

(Royal Society Publishing, 2015-07-20)
Identifying the germline genes involved in immunoglobulin rearrangements is an essential first step in the analysis of antibody repertoires. Based on our prior work in analysing diverse recombinant viruses, we present ...
• #### Association with pathogenic bacteria affects life-history traits and population growth in Caenorhabditis elegans. ﻿

(Wiley, 2015-03-23)
Determining the relationship between individual life-history traits and population dynamics is an essential step to understand and predict natural selection. Model organisms that can be conveniently studied experimentally ...
• #### Availability of Information on Reptile Health and Welfare from Stores Selling Reptiles ﻿

(Scientific Research, 2016-03-17)
The popularity of keeping reptiles such as snakes and lizards is ever increasing. The health and welfare of these animals depends on the knowledge and understanding of their environmental and nutritional needs. But where ...
• #### Bat trait, genetic and pathogen data from large-scale investigations of African fruit bats, Eidolon helvum ﻿

(Nature Publishing Group, 2016-08-01)
Bats, including African straw-coloured fruit bats (Eidolon helvum), have been highlighted as reservoirs of many recently emerged zoonotic viruses. This common, widespread and ecologically important species was the focus ...
• #### Bayesian Model Choice in Cumulative Link Ordinal Regression Models ﻿

(International Society for Bayesian Analysis, 2015-01-28)
The use of the proportional odds (PO) model for ordinal regression is ubiquitous in the literature. If the assumption of parallel lines does not hold for the data, then an alternative is to specify a non-proportional odds ...
• #### Bioassay of prion-infected blood plasma in PrP transgenic $\textit{Drosophila}$ ﻿

(Portland Press, 2016-12-01)
In pursuit of a tractable bioassay to assess blood prion infectivity, we have generated prion protein (PrP) transgenic $\textit{Drosophila}$, which show a neurotoxic phenotype in adulthood after exposure to exogenous prions ...