Now showing items 1-20 of 171

    • A Bayesian Change point model for differential gene expression patterns of the DosR regulon of Mycobacterium tuberculosis 

      Zhang, Yi; Hatch, Kim A.; Wernisch, Lorenz; Bacon, Joanna (2008-02-22)
      Abstract Background Low oxygen availability has been shown previously to stimulate M. tuberculosis to establish non-replicative persistence in vitro. The two component sensor/regulator dosRS is a major mediator in the ...
    • A random effects variance shift model for detecting and accommodating outliers in meta-analysis 

      Gumedze, Freedom N.; Jackson, Dan (2011-02-16)
      Abstract Background Meta-analysis typically involves combining the estimates from independent studies in order to estimate a parameter of interest across a population of studies. However, outliers often occur even under ...
    • The accuracy of diagnostic coding for acute kidney injury in England - a single centre study 

      Tomlinson, Laurie Alexandra; Riding, Alex M; Payne, Rupert; Abel, Gary Alexander; Tomson, Charles R; Wilkinson, Ian Boden; Roland, Martin et al. (2013-03-13)
    • Advance care discussions with young people affected by life-limiting neuromuscular diseases: A systematic literature review and narrative synthesis 

      Hiscock, A; Kuhn, I; Barclay, Stephen Ian (Elsevier, 2017-02)
      End of life care policy in the UK advocates open discussions between health professionals and patients as the end of life approaches. Despite well documented understanding of the progression of life-limiting neuromuscular ...
    • Alcohol in older people: systematic reviews of interventions and context 

      Kelly, Sarah Anne; Olanrewaju, O; Cowan, A; Brayne, Carol Elspeth; Lafortune, Louise (Elsevier, 2016-11-25)
      BACKGROUND: Harmful alcohol consumption is increasing in older people because of an ageing population and heavier consumption in the generation now reaching older age. This work was part of a comprehensive evidence synthesis ...
    • An integrated machine learning approach for predicting DosR-regulated genes in Mycobacterium tuberculosis 

      Zhang, Yi; Hatch, Kim A.; Bacon, Joanna; Wernisch, Lorenz (2010-03-31)
      Abstract Background DosR is an important regulator of the response to stress such as limited oxygen availability in Mycobacterium tuberculosis. Time course gene expression data enable us to dissect this response on the ...
    • An investigation of factors associated with psychiatric hospital admission despite the presence of crisis resolution teams 

      Cotton, Mary-Anne; Johnson, Sonia; Bindman, Jonathan; Sandor, Andrew; White, Ian R; Thornicroft, Graham; Nolan, Fiona et al. (2007-10-02)
      Abstract Background Crisis resolution teams (CRTs) provide a community alternative to psychiatric hospital admission for patients presenting in crisis. Little is known about the characteristics of patients admitted despite ...
    • ANGPTL3 Deficiency and Protection Against Coronary Artery Disease 

      Stitziel, NO; Khera, AV; Wang, X; Bierhals, AJ; Vourakis, AC; Sperry, AE; Natarajan, P et al. (Elsevier, 2017-04-25)
      Background Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). ...
    • Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study. 

      van, Capelleveen JC; Bernelot, Moens SJ; Yang, X; Kastelein, JJP; Wareham, Nicholas John; Zwinderman, AH; Stroes, ESG et al. (American Heart Association, 2017-06)
      $\textbf{Objective-}$Apolipoprotein C-III (apoC-III) is a key regulator of triglyceride metabolism. Elevated triglyceride-rich lipoproteins and apoC-III levels are causally linked to coronary artery disease (CAD) risk. The ...
    • Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis. 

      Saleheen, Danish; Haycock, Philip C; Zhao, Wei; Rasheed, Asif; Taleb, Adam; Imran, Atif; Abbas, Shahid et al. (2017-07)
    • Are brief interventions to increase physical activity cost-effective? A systematic review 

      Vijay, GC; Suhrcke, Marc; Hardeman, Wendy; Sutton, Stephen Robert (2015-10-05)
    • Assessing the impact of road traffic on cycling for leisure and cycling to work 

      Foster, Charles E; Panter, Jenna; Wareham, Nicholas John (2011-06-10)
    • Association analysis identifies 65 new breast cancer risk loci 

      Michailidou, K; Lindström, S; Dennis, J; Beesley, J; Hui, S; Kar, S; Lemaçon, A et al. (Nature Publishing Group, 2017-10-23)
      Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. ...
    • Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies 

      Davis, Daniel Harvey; Muniz-Terrera, G; Keage, HAD; Stephan, BCM; Fleming, Frances Jane; Ince, PG; Matthews, FE et al. (American Medical Association, 2017-03-01)
      Importance: Delirium is associated with accelerated cognitive decline. The pathologic substrates of this association are not yet known, that is, whether they are the same as those associated with dementia, are independent, ...
    • The association of education with body mass index and waist circumference in the EPIC-PANACEA study 

      Hermann, Silke; Rohrmann, Sabine; Linseisen, Jakob; May, Anne M; Kunst, Anton; Besson, Herve; Romaguera, Dora et al. (2011-03-17)
    • Association of Genetic Variants Related to Serum Calcium Levels With Coronary Artery Disease and Myocardial Infarction 

      Larsson, SC; Burgess, Stephen; Michaëlsson, K (American Medical Association, 2017-07-25)
      Importance: Serum calcium has been associated with cardiovascular disease in observational studies and evidence from randomized clinical trials indicates that calcium supplementation, which raises serum calcium levels, may ...
    • Associations between diagnostic activity and measures of patient experience in primary care: A cross-sectional ecological study of English general practices 

      Lyratzopoulos, Georgios; Martins Mendonca, Silvia Cristina; Gildea, C; McPhail, S; Peake, MD; Rubin, G; Singh, H et al.
      Background: Lower use of endoscopies and urgent referrals for suspected cancer has been linked to poorer outcomes for cancer patients; it is important to examine potential predictors of variable use. Aim: To examine ...
    • Associations with intraocular pressure across Europe: The European Eye Epidemiology (E$^3$) Consortium 

      Khawaja, Anthony P; Springelkamp, Henriët; Creuzot-Garcher, Catherine; Delcourt, Cécile; Hofman, Albert; Höhn, René; Iglesias, Adriana I et al. (2016-09-09)