Now showing items 1-20 of 126

• #### A Bayesian Change point model for differential gene expression patterns of the DosR regulon of Mycobacterium tuberculosis ﻿

(2008-02-22)
Abstract Background Low oxygen availability has been shown previously to stimulate M. tuberculosis to establish non-replicative persistence in vitro. The two component sensor/regulator dosRS is a major mediator in the ...
• #### A commentary on studies presenting projections of the future prevalence of dementia ﻿

(2013-01-02)
Abstract Background Population ageing over the first half of this century is likely to lead to dramatic increases in the prevalence of dementia. This will affect all regions of the world, but particularly developing regions. ...
• #### A random effects variance shift model for detecting and accommodating outliers in meta-analysis ﻿

(2011-02-16)
Abstract Background Meta-analysis typically involves combining the estimates from independent studies in order to estimate a parameter of interest across a population of studies. However, outliers often occur even under ...
• #### Advance care discussions with young people affected by life-limiting neuromuscular diseases: A systematic literature review and narrative synthesis ﻿

(2017-02-01)
• #### Alcohol in older people: systematic reviews of interventions and context ﻿

(Elsevier, 2016-11-25)
BACKGROUND: Harmful alcohol consumption is increasing in older people because of an ageing population and heavier consumption in the generation now reaching older age. This work was part of a comprehensive evidence synthesis ...
• #### An exploration of the missing data mechanism in an Internet based smoking cessation trial ﻿

(2012-10-15)
Abstract Background Missing outcome data are very common in smoking cessation trials. It is often assumed that all such missing data are from participants who have been unsuccessful in giving up smoking (&#8220;missing=s ...
• #### An integrated machine learning approach for predicting DosR-regulated genes in Mycobacterium tuberculosis ﻿

(2010-03-31)
Abstract Background DosR is an important regulator of the response to stress such as limited oxygen availability in Mycobacterium tuberculosis. Time course gene expression data enable us to dissect this response on the ...
• #### An investigation of factors associated with psychiatric hospital admission despite the presence of crisis resolution teams ﻿

(2007-10-02)
Abstract Background Crisis resolution teams (CRTs) provide a community alternative to psychiatric hospital admission for patients presenting in crisis. Little is known about the characteristics of patients admitted despite ...
• #### An investigation of the population impact of variation in HbA1c levels in older people in England and Wales: from a population based multi-centre longitudinal study ﻿

(2008-02-11)
Abstract Background Diabetes is common in the older population and is increasing. Glycated hemoglobin (HbA1c) is an indicator of average blood glucose concentration over the past three months. The HbA1c test is currently ...
• #### Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study. ﻿

(American Heart Association, 2017-06)
$\textbf{Objective-}$Apolipoprotein C-III (apoC-III) is a key regulator of triglyceride metabolism. Elevated triglyceride-rich lipoproteins and apoC-III levels are causally linked to coronary artery disease (CAD) risk. The ...
• #### Are brief interventions to increase physical activity cost-effective? A systematic review ﻿

(BMJ Group, 2015-10-05)
Objective To determine whether brief interventions promoting physical activity are cost-effective in primary care or community settings. Design Systematic review of economic evaluations. Methods and data sources ...
• #### Assessing subgroup effects with binary data: can the use of different effect measures lead to different conclusions? ﻿

(2005-04-29)
Abstract Background In order to use the results of a randomised trial, it is necessary to understand whether the overall observed benefit or harm applies to all individuals, or whether some subgroups receive more benefit ...
• #### Assessing the impact of road traffic on cycling for leisure and cycling to work ﻿

(2011-06-10)
Abstract Background To explore the relationship between leisure and commuter cycling with objectively measured levels of road traffic and whether any relationship was affected by traffic levels directly outside of home or ...
• #### Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies ﻿

(American Medical Association, 2017-03-01)
Importance: Delirium is associated with accelerated cognitive decline. The pathologic substrates of this association are not yet known, that is, whether they are the same as those associated with dementia, are independent, ...
• #### Associations of health, physical activity and weight status with motorised travel and transport carbon dioxide emissions: a cross-sectional, observational study ﻿

(2012-08-03)
Abstract Background Motorised travel and associated carbon dioxide (CO2) emissions generate substantial health costs; in the case of motorised travel, this may include contributing to rising obesity levels. Obesity has in ...
• #### Associations with intraocular pressure across Europe: The European Eye Epidemiology (E$^3$) Consortium ﻿

(Springer, 2016-09-09)
Raised intraocular pressure (IOP) is the most important risk factor for developing glaucoma, the second commonest cause of blindness globally. Understanding associations with IOP and variations in IOP between countries may ...
• #### Barriers and facilitators to staying in work after stroke: insight from an online forum. ﻿

(2016-04-06)
OBJECTIVE: To explore barriers and facilitators to staying in work following stroke. DESIGN: Qualitative analysis of posts regarding staying in work following stroke using the archives of an online forum for stroke survivors. ...
• #### Barriers and Facilitators to the Uptake and Maintenance of Healthy Behaviours by People at Mid-Life: A Rapid Systematic Review ﻿

(PLOS, 2016-01-27)
$\textbf{Background}$ With an ageing population, there is an increasing societal impact of ill health in later life. People who adopt healthy behaviours are more likely to age successfully. To engage people in health ...

(2015-01)
• #### Benefits, pitfalls, and future design of population-based registers in neurodegenerative disease ﻿

(Wolters Kluwer, 2017-06-13)
Population-based disease registers identify and characterize all cases of disease, including those that might otherwise be neglected. Prospective population-based registers in neurodegeneration are necessary to provide ...