Now showing items 1-20 of 257

    • A Bayesian Change point model for differential gene expression patterns of the DosR regulon of Mycobacterium tuberculosis 

      Zhang, Yi; Hatch, Kim A.; Wernisch, Lorenz; Bacon, Joanna (2008-02-22)
      Abstract Background Low oxygen availability has been shown previously to stimulate M. tuberculosis to establish non-replicative persistence in vitro. The two component sensor/regulator dosRS is a major mediator in the ...
    • A random effects variance shift model for detecting and accommodating outliers in meta-analysis 

      Gumedze, Freedom N.; Jackson, Dan (2011-02-16)
      Abstract Background Meta-analysis typically involves combining the estimates from independent studies in order to estimate a parameter of interest across a population of studies. However, outliers often occur even under ...
    • Abdominal aortic aneurysms in women - Authors' reply. 

      Powell, Janet T; Ulug, Pinar; Sweeting, Michael John; von Allmen, Regula S; Thompson, Simon Gregory (2017-10-05)
      We thank Kosmas Paraskevas for his interest in our study.The practice of medicine should be based on the best available evidence. The best evidence for when women lose their morphological suitability for endovascular ...
    • The accuracy of diagnostic coding for acute kidney injury in England - a single centre study 

      Tomlinson, Laurie Alexandra; Riding, Alex M; Payne, Rupert; Abel, Gary Alexander; Tomson, Charles R; Wilkinson, Ian Boden; Roland, Martin et al. (2013-03-13)
      Abstract Background Acute kidney injury (AKI) is an independent risk factor for mortality and is responsible for a significant burden of healthcare expenditure, so accurate measurement of its incidence is important. ...
    • Adjusting for cross-cultural differences in computer-adaptive tests of quality of life. 

      Gibbons, Christopher Julian; Skevington, SM; WHOQOL Group, (Springer Nature, 2017-12-04)
      Quality of life differs between individuals and across different cultures. Traditional methods of comparing quality of life (QoL) between cultures, for example comparing ordinal summary scores from scales in different ...
    • Advance care discussions with young people affected by life-limiting neuromuscular diseases: A systematic literature review and narrative synthesis 

      Hiscock, A; Kuhn, I; Barclay, Stephen Ian (Elsevier, 2017-02)
      End of life care policy in the UK advocates open discussions between health professionals and patients as the end of life approaches. Despite well documented understanding of the progression of life-limiting neuromuscular ...
    • Adverse childhood experiences (ACEs) and later-life depression: perceived social support as a potential protective factor. 

      Sinnott, Carol; Cheong, EV; Dahly, D; Kearney, PM
      Objective To investigate associations between adverse childhood experiences (ACEs) and later-life depressive symptoms; and to explore whether perceived social support (PSS) moderates these. Method We analysed baseline ...
    • Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study. 

      Lipnicki, Darren M; Crawford, John D; Dutta, Rajib; Thalamuthu, Anbupalam; Kochan, Nicole A; Andrews, Gavin; Lima-Costa, M Fernanda et al. (2017-03-21)
    • Alcohol in older people: systematic reviews of interventions and context 

      Kelly, Sarah Anne; Olanrewaju, O; Cowan, A; Brayne, Carol Elspeth; Lafortune, Louise (Elsevier, 2016-11-25)
      BACKGROUND: Harmful alcohol consumption is increasing in older people because of an ageing population and heavier consumption in the generation now reaching older age. This work was part of a comprehensive evidence synthesis ...
    • An integrated machine learning approach for predicting DosR-regulated genes in Mycobacterium tuberculosis 

      Zhang, Yi; Hatch, Kim A.; Bacon, Joanna; Wernisch, Lorenz (2010-03-31)
      Abstract Background DosR is an important regulator of the response to stress such as limited oxygen availability in Mycobacterium tuberculosis. Time course gene expression data enable us to dissect this response on the ...
    • An investigation of factors associated with psychiatric hospital admission despite the presence of crisis resolution teams 

      Cotton, Mary-Anne; Johnson, Sonia; Bindman, Jonathan; Sandor, Andrew; White, Ian R; Thornicroft, Graham; Nolan, Fiona et al. (2007-10-02)
      Abstract Background Crisis resolution teams (CRTs) provide a community alternative to psychiatric hospital admission for patients presenting in crisis. Little is known about the characteristics of patients admitted despite ...
    • ANGPTL3 Deficiency and Protection Against Coronary Artery Disease 

      Stitziel, NO; Khera, AV; Wang, X; Bierhals, AJ; Vourakis, AC; Sperry, AE; Natarajan, P et al. (Elsevier, 2017-04-25)
      Background Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). ...
    • Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study. 

      van, Capelleveen JC; Bernelot, Moens SJ; Yang, X; Kastelein, JJP; Wareham, Nicholas John; Zwinderman, AH; Stroes, ESG et al. (American Heart Association, 2017-06)
      $\textbf{Objective-}$Apolipoprotein C-III (apoC-III) is a key regulator of triglyceride metabolism. Elevated triglyceride-rich lipoproteins and apoC-III levels are causally linked to coronary artery disease (CAD) risk. The ...
    • Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis. 

      Saleheen, Danish; Haycock, Philip C; Zhao, Wei; Rasheed, Asif; Taleb, Adam; Imran, Atif; Abbas, Shahid et al. (2017-07)
    • Are brief interventions to increase physical activity cost-effective? A systematic review 

      Vijay, GC; Suhrcke, Marc; Hardeman, Wendy; Sutton, Stephen Robert (2015-10-05)
    • Are within-person Numerical Rating Scale (NRS) ratings of breathlessness ‘on average’ valid in advanced disease for patients and for patients’ informal carers? 

      Wade, Joshua; Mendonca, Silvia; Booth, Sara; Ewing, Gail; Gardener, A Carole; Farquhar, Morag Catriona (2017-10)
      Introduction The Numerical Rating Scale (NRS) is frequently used to assess patient reported breathlessness in both a research and clinical context. A subgroup report average breathlessness as worse than worst breathlessness ...
    • Assessing the impact of road traffic on cycling for leisure and cycling to work 

      Foster, Charles E; Panter, Jenna; Wareham, Nicholas John (2011-06-10)
    • Association analysis identifies 65 new breast cancer risk loci 

      Michailidou, K; Lindström, S; Dennis, J; Beesley, J; Hui, S; Kar, S; Lemaçon, A et al. (Nature Publishing Group, 2017-10-23)
      Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. ...