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dc.contributor.authorMaier, Lisa Men
dc.contributor.authorSmyth, Deborah Jen
dc.contributor.authorVella, Adrianen
dc.contributor.authorPayne, Felicityen
dc.contributor.authorCooper, Jasonen
dc.contributor.authorPask, Rebeccaen
dc.contributor.authorLowe, Christopher Een
dc.contributor.authorHulme, John Sen
dc.contributor.authorSmink, Luc Jen
dc.contributor.authorFraser, Heatheren
dc.contributor.authorMoule, Carolynen
dc.contributor.authorHunter, Kara Men
dc.contributor.authorChamberlain, Giselleen
dc.contributor.authorWalker, Neil Men
dc.contributor.authorNutland, Sarahen
dc.contributor.authorUndlien, Dag Een
dc.contributor.authorRonningen, Kjersti Sen
dc.contributor.authorGuja, Cristianen
dc.contributor.authorIonescu-Tirgoviste, Constantinen
dc.contributor.authorSavage, David Aen
dc.contributor.authorStrachan, David Pen
dc.contributor.authorPeterson, Laurenceen
dc.contributor.authorTodd, Johnen
dc.contributor.authorWicker, Lindaen
dc.contributor.authorTwells, Rebecca CJen
dc.date.accessioned2011-06-14T14:42:58Z
dc.date.available2011-06-14T14:42:58Z
dc.date.issued2005-02-18en
dc.identifier.citationBMC Genetics 2005, 6:9
dc.identifier.issn1471-2156
dc.identifier.urihttp://www.dspace.cam.ac.uk/handle/1810/237687
dc.description.abstractAbstract Background One strategy to help identify susceptibility genes for complex, multifactorial diseases is to map disease loci in a representative animal model of the disorder. The nonobese diabetic (NOD) mouse is a model for human type 1 diabetes. Linkage and congenic strain analyses have identified several NOD mouse Idd (insulin dependent diabetes) loci, which have been mapped to small chromosome intervals, for which the orthologous regions in the human genome can be identified. Here, we have conducted re-sequencing and association analysis of six orthologous genes identified in NOD Idd loci: NRAMP1/SLC11A1 (orthologous to Nramp1/Slc11a1 in Idd5.2), FRAP1 (orthologous to Frap1 in Idd9.2), 4-1BB/CD137/TNFRSF9 (orthologous to 4-1bb/Cd137/Tnrfrsf9 in Idd9.3), CD101/IGSF2 (orthologous to Cd101/Igsf2 in Idd10), B2M (orthologous to B2m in Idd13) and VAV3 (orthologous to Vav3 in Idd18). Results Re-sequencing of a total of 110 kb of DNA from 32 or 96 type 1 diabetes cases yielded 220 single nucleotide polymorphisms (SNPs). Sixty-five SNPs, including 54 informative tag SNPs, and a microsatellite were selected and genotyped in up to 1,632 type 1 diabetes families and 1,709 cases and 1,829 controls. Conclusion None of the candidate regions showed evidence of association with type 1 diabetes (P values > 0.2), indicating that common variation in these key candidate genes does not play a major role in type 1 diabetes susceptibility in the European ancestry populations studied.
dc.languageEnglishen
dc.language.isoen
dc.titleConstruction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetesen
dc.typeArticle
dc.date.updated2011-06-14T14:42:58Z
dc.description.versionRIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.en
dc.rights.holderMaier et al.; licensee BioMed Central Ltd.
prism.publicationDate2005en
dcterms.dateAccepted2005-02-18en
rioxxterms.versionofrecord10.1186/1471-2156-6-9en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2005-02-18en
dc.identifier.eissn1471-2156
rioxxterms.typeJournal Article/Reviewen


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