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dc.contributor.authorAgusti, Alvaren
dc.contributor.authorCalverley, Peter MAen
dc.contributor.authorCelli, Bartolomeen
dc.contributor.authorCoxson, Harvey Oen
dc.contributor.authorEdwards, Lisa Den
dc.contributor.authorLomas, Daviden
dc.contributor.authorMacNee, Williamen
dc.contributor.authorMiller, Bruce Een
dc.contributor.authorRennard, Steveen
dc.contributor.authorSilverman, Edwin Ken
dc.contributor.authorTal-Singer, Ruthen
dc.contributor.authorWouters, Emielen
dc.contributor.authorYates, Julie Cen
dc.contributor.authorVestbo, Jorgenen
dc.contributor.author(ECLIPSE), Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpointsen
dc.date.accessioned2011-06-16T15:51:43Z
dc.date.available2011-06-16T15:51:43Z
dc.date.issued2010-09-10en
dc.identifier.issn1465-9921
dc.identifier.urihttp://www.dspace.cam.ac.uk/handle/1810/237802
dc.description.abstractAbstract Background Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE). Methods We studied 2164 clinically stable COPD patients, 337 smokers with normal lung function and 245 never smokers. In these individuals, we measured clinical parameters, nutritional status, spirometry, exercise tolerance, and amount of emphysema by computed tomography. Results COPD patients were slightly older than controls and had more pack years of smoking than smokers with normal lung function. Co-morbidities were more prevalent in COPD patients than in controls, and occurred to the same extent irrespective of the GOLD stage. The severity of airflow limitation in COPD patients was poorly related to the degree of breathlessness, health status, presence of co-morbidity, exercise capacity and number of exacerbations reported in the year before the study. The distribution of these variables within each GOLD stage was wide. Even in subjects with severe airflow obstruction, a substantial proportion did not report symptoms, exacerbations or exercise limitation. The amount of emphysema increased with GOLD severity. The prevalence of bronchiectasis was low (4%) but also increased with GOLD stage. Some gender differences were also identified. Conclusions The clinical manifestations of COPD are highly variable and the degree of airflow limitation does not capture the heterogeneity of the disease.
dc.languageEnglishen
dc.language.isoen
dc.titleCharacterisation of COPD heterogeneity in the ECLIPSE cohorten
dc.typeArticle
dc.date.updated2011-06-16T15:51:43Z
dc.description.versionRIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.en
dc.rights.holderAgusti et al.; licensee BioMed Central Ltd.
prism.publicationDate2010en
dcterms.dateAccepted2010-09-10en
rioxxterms.versionofrecord10.1186/1465-9921-11-122en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2010-09-10en
dc.identifier.eissn1465-993X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G0500306)


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