Show simple item record

dc.contributor.authorBrown, Damien Pen
dc.contributor.authorJones, Desmonden
dc.contributor.authorAnderson, Katie Jen
dc.contributor.authorLapaque, Nicolasen
dc.contributor.authorBuerki, Robin Aen
dc.contributor.authorTrowsdale, Johnen
dc.contributor.authorAllen, Rachel Len
dc.date.accessioned2011-06-16T16:12:59Z
dc.date.available2011-06-16T16:12:59Z
dc.date.issued2009-10-27en
dc.identifier.citationBMC Immunology 2009, 10:56
dc.identifier.issn1471-2172
dc.identifier.urihttp://www.dspace.cam.ac.uk/handle/1810/237895
dc.description.abstractAbstract Background Leukocyte Ig-like receptors (LILR) are a family of innate immune receptors with immunomodulatory functions. High-level expression of the receptors LILRB2 (ILT4) and LILRB4 (ILT3) is a feature of tolerogenic antigen presenting cells and has been observed in cancer and transplant situations. There are relatively few studies regarding these receptors in the context of infection and it is not yet clear how LILRB4 exerts its inhibitory effects. Results We studied the effects of LILRB4 ligation on antigen presenting cell phenotype, and the expression of LILRB2 and LILRB4 on Salmonella-infected antigen presenting cells. Ligation of LILRB4 throughout in vitro culture of dendritic cells led to an upregulation of the co-stimulatory protein CD86. Alterations in the production of IL-8 and IL-10 by LILRB4-ligated macrophages were also observed. Infection with Salmonella typhimurium or TLR stimulation with Salmonella components led to an upregulation of LILRB2 and LILRB4. Conclusion Our results indicate that the inhibitory effects of LILRB4 do not result from a failure to upregulate co-stimulatory proteins. In addition to the high level expression that can render antigen presenting cells tolerogenic, there may be a role for lower level expression and activity of LILRB2 and LILRB4 in response to TLR signalling during an immune response to bacterial infection.
dc.languageEnglishen
dc.language.isoen
dc.titleThe inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infectionen
dc.typeArticle
dc.date.updated2011-06-16T16:13:00Z
dc.description.versionRIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.en
dc.rights.holderBrown et al.; licensee BioMed Central Ltd.
prism.publicationDate2009en
dcterms.dateAccepted2009-10-27en
rioxxterms.versionofrecord10.1186/1471-2172-10-56en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2009-10-27en
dc.contributor.orcidTrowsdale, John [0000-0002-0150-5698]
dc.identifier.eissn1471-2172
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G0401569)


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record