Randomised controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial
Authors
Finucane, Francis M
Horton, Jessica
Purslow, Lisa R
Besson, Herve
Horton, Kenneth
De, Lucia Rolfe Ema
Sleigh, Alison
Martin, Helen
Ahie, Sayer Avan
Cooper, Cyrus
Ekelund, Ulf
Publication Date
2009-06-19ISSN
1472-6823
Language
English
Type
Article
Metadata
Show full item recordCitation
Finucane, F. M., Horton, J., Purslow, L. R., Savage, D., Brage, S., Besson, H., Horton, K., et al. (2009). Randomised controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial. http://www.dspace.cam.ac.uk/handle/1810/237910
Abstract
Abstract Background While there are compelling observational data confirming that individuals who exercise are healthier, the efficacy of aerobic exercise interventions to reduce metabolic risk and improve insulin sensitivity in older people has not been fully elucidated. Furthermore, while low birth weight has been shown to predict adverse health outcomes later in life, its influence on the response to aerobic exercise is unknown. Our primary objective is to assess the efficacy of a fully supervised twelve week aerobic exercise intervention in reducing clustered metabolic risk in healthy older adults. A secondary objective is to determine the influence of low birth weight on the response to exercise in this group. Methods/Design We aim to recruit 100 participants born between 1931–1939, from the Hertfordshire Cohort Study and randomly assign them to no intervention or to 36 fully supervised one hour sessions on a cycle ergometer, over twelve weeks. Each participant will undergo detailed anthropometric and metabolic assessment pre- and post-intervention, including muscle biopsy, magnetic resonance imaging and spectroscopy, objective measurement of physical activity and sub-maximal fitness testing. Discussion Given the extensive phenotypic characterization, this study will provide valuable insights into the mechanisms underlying the beneficial effects of aerobic exercise as well as the efficacy, feasibility and safety of such interventions in this age group. Trial Registration Current Controlled Trials: ISRCTN60986572
Sponsorship
MRC (G0701532)
MRC (MC_UU_12015/1)
MRC (MC_UU_12015/4)
MRC (MC_UU_12015/3)
MRC (G0600717B)
Medical Research Council (MC_U106179474)
Identifiers
This record's URL: http://www.dspace.cam.ac.uk/handle/1810/237910
Rights
Rights Holder: Finucane et al.; licensee BioMed Central Ltd.
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