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dc.contributor.authorFinucane, Francis Men
dc.contributor.authorHorton, Jessicaen
dc.contributor.authorPurslow, Lisa Ren
dc.contributor.authorSavage, Daviden
dc.contributor.authorBrage, Sorenen
dc.contributor.authorBesson, Herveen
dc.contributor.authorHorton, Kennethen
dc.contributor.authorDe, Lucia Rolfe Emaen
dc.contributor.authorSleigh, Alisonen
dc.contributor.authorSharp, Stephenen
dc.contributor.authorMartin, Helenen
dc.contributor.authorAhie, Sayer Avanen
dc.contributor.authorCooper, Cyrusen
dc.contributor.authorEkelund, Ulfen
dc.contributor.authorGriffin, Simonen
dc.contributor.authorWareham, Nicholasen
dc.date.accessioned2011-06-16T16:15:26Z
dc.date.available2011-06-16T16:15:26Z
dc.date.issued2009-06-19en
dc.identifier.issn1472-6823
dc.identifier.urihttp://www.dspace.cam.ac.uk/handle/1810/237910
dc.description.abstractAbstract Background While there are compelling observational data confirming that individuals who exercise are healthier, the efficacy of aerobic exercise interventions to reduce metabolic risk and improve insulin sensitivity in older people has not been fully elucidated. Furthermore, while low birth weight has been shown to predict adverse health outcomes later in life, its influence on the response to aerobic exercise is unknown. Our primary objective is to assess the efficacy of a fully supervised twelve week aerobic exercise intervention in reducing clustered metabolic risk in healthy older adults. A secondary objective is to determine the influence of low birth weight on the response to exercise in this group. Methods/Design We aim to recruit 100 participants born between 1931–1939, from the Hertfordshire Cohort Study and randomly assign them to no intervention or to 36 fully supervised one hour sessions on a cycle ergometer, over twelve weeks. Each participant will undergo detailed anthropometric and metabolic assessment pre- and post-intervention, including muscle biopsy, magnetic resonance imaging and spectroscopy, objective measurement of physical activity and sub-maximal fitness testing. Discussion Given the extensive phenotypic characterization, this study will provide valuable insights into the mechanisms underlying the beneficial effects of aerobic exercise as well as the efficacy, feasibility and safety of such interventions in this age group. Trial Registration Current Controlled Trials: ISRCTN60986572
dc.languageEnglishen
dc.language.isoen
dc.titleRandomised controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trialen
dc.typeArticle
dc.date.updated2011-06-16T16:15:26Z
dc.description.versionRIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.en
dc.rights.holderFinucane et al.; licensee BioMed Central Ltd.
prism.publicationDate2009en
dcterms.dateAccepted2009-06-19en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2009-06-19en
dc.contributor.orcidSavage, David [0000-0002-7857-7032]
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
dc.contributor.orcidSharp, Stephen [0000-0003-2375-1440]
dc.contributor.orcidGriffin, Simon [0000-0002-2157-4797]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.identifier.eissn1472-6823
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G0701532)
pubs.funder-project-idMRC (MC_UU_12015/1)
pubs.funder-project-idMRC (MC_UU_12015/4)
pubs.funder-project-idMRC (MC_UU_12015/3)
pubs.funder-project-idMRC (G0600717B)
pubs.funder-project-idMedical Research Council (MC_U106179474)


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