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dc.contributor.authorMorris, Gerard AJen
dc.contributor.authorLowe, Christopheren
dc.contributor.authorCooper, Jasonen
dc.contributor.authorPayne, Felicityen
dc.contributor.authorVella, Adrianen
dc.contributor.authorGodfrey, Lisa Men
dc.contributor.authorHulme, John Sen
dc.contributor.authorWalker, Neil Men
dc.contributor.authorHealy, Barry Cen
dc.contributor.authorLam, Alex Cen
dc.contributor.authorLyons, Paulen
dc.contributor.authorTodd, Johnen
dc.date.accessioned2011-06-16T16:49:06Z
dc.date.available2011-06-16T16:49:06Z
dc.date.issued2006-02-22en
dc.identifier.citationBMC Genetics 2006, 7:12
dc.identifier.issn1471-2156
dc.identifier.urihttp://www.dspace.cam.ac.uk/handle/1810/238076
dc.description.abstractAbstract Background The aetiology of the autoimmune disease type 1 diabetes (T1D) involves many genetic and environmental factors. Evidence suggests that innate immune responses, including the action of interferons, may also play a role in the initiation and/or pathogenic process of autoimmunity. In the present report, we have adopted a linkage disequilibrium (LD) mapping approach to test for an association between T1D and three regions encompassing 13 interferon alpha (IFNA) genes, interferon omega-1 (IFNW1), interferon beta-1 (IFNB1), interferon gamma (IFNG) and the interferon consensus-sequence binding protein 1 (ICSBP1). Results We identified 238 variants, most, single nucleotide polymorphisms (SNPs), by sequencing IFNA, IFNB1, IFNW1 and ICSBP1, 98 of which where novel when compared to dbSNP build 124. We used polymorphisms identified in the SeattleSNP database for INFG. A set of tag SNPs was selected for each of the interferon and interferon-related genes to test for an association between T1D and this complex gene family. A total of 45 tag SNPs were selected and genotyped in a collection of 472 multiplex families. Conclusion We have developed informative sets of SNPs for the interferon and interferon related genes. No statistical evidence of a major association between T1D and any of the interferon and interferon related genes tested was found.
dc.languageEnglishen
dc.language.isoen
dc.titlePolymorphism discovery and association analyses of the interferon genes in type 1 diabetesen
dc.typeArticle
dc.date.updated2011-06-16T16:49:06Z
dc.description.versionRIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.en
dc.rights.holderMorris et al.; licensee BioMed Central Ltd.
prism.publicationDate2006en
dcterms.dateAccepted2006-02-22en
rioxxterms.versionofrecord10.1186/1471-2156-7-12en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2006-02-22en
dc.contributor.orcidLyons, Paul [0000-0001-7035-8997]
dc.identifier.eissn1471-2156
rioxxterms.typeJournal Article/Reviewen


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