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dc.contributor.authorWard, Heatheren
dc.contributor.authorChapelais, Gaelleen
dc.contributor.authorKuhnle, Gunter GCen
dc.contributor.authorLuben, Roberten
dc.contributor.authorKhaw, Kay-Teeen
dc.contributor.authorBingham, Sheilaen
dc.date.accessioned2011-06-17T14:27:53Z
dc.date.available2011-06-17T14:27:53Z
dc.date.issued2008-04-17en
dc.identifier.citationBreast Cancer Research 2008, 10:R32
dc.identifier.issn1465-5411
dc.identifier.urihttp://www.dspace.cam.ac.uk/handle/1810/238204
dc.description.abstractAbstract Introduction Phytoestrogens are a group of compounds found in plants that structurally resemble the hormone oestradiol, and thus have the potential to act as oestrogen agonists or antagonists. Their potential effects may alter the risk of breast cancer, but only a limited range of phytoestrogens has been examined in prospective cohort studies. Methods Serum and urine samples from 237 incident breast cancer cases and 952 control individuals (aged 45 to 75 years) in the European Prospective into Cancer-Norfolk cohort were analysed for seven phytoestrogens (daidzein, enterodiol, enterolactone, genistein, glycitein, o-desmethylangolensin, and equol) using liquid chromatography/mass spectrometry. Data on participants' diet, demographics, anthropometrics, and medical history were collected upon recruitment. All models were adjusted for weight, fat and energy intake, family history of breast cancer, social class, analytical batch, and factors related to oestrogen exposure. Results Urinary or serum phytoestrogens were not associated with protection from breast cancer in the European Prospective into Cancer-Norfolk cohort. Breast cancer risk was marginally increased with higher levels of total urinary isoflavones (odds ratio = 1.08 (95% confidence interval = 1.00 to 1.16), P = 0.055); among those with oestrogen receptor-positive tumours, the risk of breast cancer was increased with higher levels of urinary equol (odds ratio = 1.07 (95% confidence interval = 1.01 to 1.12), P = 0.013). Conclusion There was limited evidence of an association between phytoestrogen biomarkers and breast cancer risk in the present study. There was no indication of decreased likelihood of breast cancer with higher levels of phytoestrogen biomarkers, but the observation that some phytoestrogen biomarkers may be associated with greater risk of breast cancer warrants further study with greater statistical power.
dc.languageEnglishen
dc.language.isoen
dc.titleBreast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the EPIC-Norfolk studyen
dc.typeArticle
dc.date.updated2011-06-17T14:27:53Z
dc.description.versionRIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.en
dc.rights.holderWard et al.; licensee BioMed Central Ltd.
prism.publicationDate2008en
dcterms.dateAccepted2008-04-17en
rioxxterms.versionofrecord10.1186/bcr1995en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2008-04-17en
dc.contributor.orcidLuben, Robert [0000-0002-5088-6343]
dc.contributor.orcidKhaw, Kay-Tee [0000-0002-8802-2903]
dc.identifier.eissn1465-542X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G0401527)


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