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P53 autoantibodies in 1006 patients followed up for breast cancer.


Type

Article

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Authors

Metcalfe, S 
Wheeler, TK 
Picken, S 
Negus, S 
Jo Milner A 

Abstract

Serial plasma samples from 1006 patients with breast cancer revealed: (i) no correlation of p53 autoantibody status with disease status at the time of sample collection, or with menopausal status at time of primary diagnosis of breast cancer; (ii) 155 out of 1006 (15%) of patients were positive for p53 autoantibodies, and these patients tended to have a persistent autoantibody status throughout follow up, irrespective of disease behaviour; and (iii) where a negative autoantibody status was found at primary diagnosis of breast cancer, this negative status persisted throughout follow up, irrespective of later disease behaviour. We conclude that screening for p53 autoantibody status is not informative on residual tumour activity nor on therapeutic responsiveness.

Description

Keywords

Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Autoantibodies, Autoantigens, Breast Neoplasms, Chemotherapy, Adjuvant, Clinical Trials as Topic, Cohort Studies, Disease Progression, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Mastectomy, Menopause, Middle Aged, Neoplasm Proteins, Tamoxifen, Treatment Outcome, Tumor Suppressor Protein p53

Journal Title

Breast Cancer Res

Conference Name

Journal ISSN

1465-5411
1465-542X

Volume Title

Publisher

Springer Science and Business Media LLC