Now showing items 1-20 of 671

    • A +1 ribosomal frameshifting motif prevalent among plant amalgaviruses 

      Nibert, Max L; Pyle, Jesse D; Firth, Andrew Edwin (Elsevier, 2016-09-04)
      Multiple sequence accessions attributable to novel plant amalgaviruses have been found in the Transcriptome Shotgun Assembly database. Sixteen accessions, derived from 12 different plant species, appear to encompass the ...
    • 2014 European Conference on Donor Health and Management 

      Ramond, Anna; Angelantonio, Emanuele (Wiley, 2015-09-01)
      The first European Conference on Donor Health and Management was held in the Hague from 3th- 5th September 2014 and hosted by Sanquin, the Dutch national blood donation organization. This is the first international conference ...
    • 2016 European Guidelines on cardiovascular disease prevention in clinical practice 

      Piepoli, Massimo F; Hoes, Arno W; Agewall, Stefan; Albus, Christian; Brotons, Carlos; Catapano, Alberico L; Cooney, Marie-Therese et al. (Oxford University Press, 2016-05-23)
    • The acceptability of repeat Internet-based hybrid diet assessment of previous 24h dietary intake: Administration of the Oxford WebQ in UK Biobank 

      Galante, Julieta; Adamska, Ligia; Young, Alan; Young, Heather; Littlejohns, Thomas J; Gallacher, John; Allen, Naomi (Cambridge University Press, 2015-12-11)
      Although dietary intake over a single 24 hour period may be atypical of an individual’s habitual pattern, multiple 24-hour dietary assessments can be representative of habitual intake and help to assess seasonal variation. ...
    • The accuracy of death dates recorded in the Clinical Practice Research Datalink (CPRD) 

      Harshfield, Amelia; Rhodes, K; Barclay, Stephen Ian; Payne, R (Society for Academic Primary Care (SAPC), 2017-07-13)
      CPRD provides general practice (GOLD) data linked to several other datasets. This can reveal discrepancies in key outcomes where similar data is available in two linked data sources. We explored discrepancies between death ...
    • Accuracy of SIAscopy for pigmented skin lesions encountered in primary care: development and validation of a new diagnostic algorithm. 

      Emery, Jon D; Hunter, Judith; Watson, Antony J; Hall, Per; Moncrieff, Marc; Walter, Fiona Mary (2010-09-25)
      Abstract Background Diagnosing pigmented skin lesions in general practice is challenging. SIAscopy has been shown to increase diagnostic accuracy for melanoma in referred populations. We aimed to develop and validate a ...
    • The adaptation and uptake evaluation of an SMS text message smoking cessation programme (MiQuit) for use in antenatal care 

      Naughton, Felix Mark; Cooper, Sue; Bowker, Katharine; Campbell, Katarzyna; Sutton, Stephen Robert; Leonardi-Bee, Jo; Sloan, Melanie et al. (BMJ Group, 2015-10-22)
      Objectives: To adapt a tailored SMS text message smoking cessation intervention (MiQuit) for use without active health professional endorsement in routine antenatal care settings, to estimate ‘real world’ uptake and test ...
    • Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study 

      Ritte, Rebecca; Lukanova, Annekatrin; Berrino, Franco; Dossus, Laure; Tjønneland, Anne; Olsen, Anja; Overvad, Thure F et al. (2012-05-14)
      Abstract Introduction Associations of hormone-receptor positive breast cancer with excess adiposity are reasonably well characterized; however, uncertainty remains regarding the association of body mass index (BMI) with ...
    • Age- and tumor subtype-specific breast cancer risk estimates for CHEK2*1100delC carriers 

      Schmidt, Marjanka K; Hogervorst, Frans; van, Hien Richard; Cornelissen, Sten; Broeks, Annegien; Adank, Muriel; Meijers, Hanne et al. (American Society of Clinical Oncology, 2016)
      CHEK2*1100delC is a well-established breast cancer risk variant, most prevalent in European populations. However, there are limited data on risk of breast cancer by age and tumor subtype, limiting its usefulness in breast ...
    • Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study 

      Brunner, Clair; Davies, Neil M; Martin, Richard M; Eeles, Rosalind; Easton, Doug; Kote-Jarai, Zsofia; Amin, Al Olama Ali et al. (Wiley, 2016-09-19)
      Prostate cancer is the most common cancer in men in developed countries, and is a target for risk reduction strategies. The effects of alcohol consumption on prostate cancer incidence and survival remain unclear, potentially ...
    • Aligning the planets: The role of nurses in the care of patients with non-ST elevation myocardial infarction 

      Deaton, Mary Christine; Johnson, Rachel; Evans, Maggie; Timmis, Adam; Zaman, Justin; Hemingway, Harry; Hughes, Jacqueline et al. (Wiley, 2016-11-04)
      $\textbf{Background}$ Studies have shown variation in care for patients with non-ST elevation myocardial infarction (NSTEMI), including in the roles of specialist and advanced practice nurses in diagnosis, treatment and ...
    • The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease 

      Astle, William John; Elding, H; Jiang, T; Allen, D; Ruklisa, Dace; Mann, AL; Mead, D et al. (Elsevier, 2016-11-17)
      Many common variants have been associated with hematological traits, but identification of causal genes and pathways has proven challenging. We performed a genome-wide association analysis in the UK Biobank and INTERVAL ...
    • Altering the availability or proximity of food, alcohol and tobacco products to change their selection and consumption 

      Hollands, Gareth John; Carter, Patrice; Shemilt, I; Marteau, Theresa; Jebb, SA; Higgins, J; Ogilvie, David Bruce (Wiley-Blackwell, 2017-03-01)
      This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: 1. To assess the impact of altering the availability or proximity of: a) food products (including non-alcoholic beverages); b) alcohol ...
    • Analysis of protein-coding genetic variation in 60,706 humans. 

      Lek, Monkol; Karczewski, Konrad J; Minikel, Eric V; Samocha, Kaitlin E; Banks, Eric; Fennell, Timothy; O'Donnell-Luria, Anne H et al. (2016-08-17)
    • The androgen receptor CAG repeat polymorphism and modification of breast cancer risk in BRCA1and BRCA2mutation carriers 

      Spurdle, Amanda B; Antoniou, Antonis; Duffy, David L; Pandeya, Nirmala; Kelemen, Livia; Chen, Xiaoqing; Peock, Susan et al. (2004-12-16)
      Abstract Introduction The androgen receptor (AR) gene exon 1 CAG repeat polymorphism encodes a string of 9–32 glutamines. Women with germline BRCA1 mutations who carry at least one AR allele with 28 or more repeats have ...
    • Annexin A1 expression in breast cancer: tumor subtypes and prognosis 

      Sobral-Leite, Marcelo; Wesseling, Jelle; Smit, Vincent THBM; Nevanlinna, Heli; van, Miltenburg Martine H; Sanders, Joyce; Hofland, Ingrid et al. (BioMed Central, 2015-06-25)
      Background Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors. However, little is known about the prognostic value of ANXA1 in breast cancer. The purpose of ...
    • Antenatal Clinic and Stop Smoking Services Staff Views on “Opt-Out” Referrals for Smoking Cessation in Pregnancy: A Framework Analysis 

      Campbell, Katarzyna Anna; Bowker, Katharine Anna; Naughton, Felix; Sloan, Melanie; Cooper, Sue; Coleman, Tim (Molecular Diversity Preservation International, 2016-10-12)
      $\textbf{Introduction}$: UK guidance recommends routine exhaled carbon monoxide (CO) screening for pregnant women and “opt-out” referrals to stop smoking services (SSS) of those with CO ≥ 4 ppm. We explored staff views on ...
    • Antibiotic Consumption in Children Prior to Diagnosis of Asthma 

      Marra, Fawziah; Marra, Carlo A.; Richardson, Kathryn J.; Lynd, Larry D.; Fitzgerald, J. Mark (2011-05-31)
      AbstractBackgroundAsthma is difficult to diagnose in children and at times misdiagnosis of an infection can occur. However, little is known about the magnitude and patterns of antibiotic consumption in children with asthma ...
    • AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials 

      Wheeler, Graham M; Sweeting, Michael John; Mander, Adrian Paul (PLOS, 2016-07-12)
      In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and ...
    • Applying the Behavior Change Technique (BCT) Taxonomy v1: A study of coder training 

      Wood, Caroline E; Richardson, Michelle; Johnston, Marie; Abraham, Charles; Francis, Jill; Hardeman, Wendy; Michie, Susan (2014-11-19)
      BACKGROUND: Behavior Change Technique Taxonomy v1 (BCTTv1) has been used to detect active ingredients of interventions. PURPOSE: Evaluate effectiveness of user training in improving reliable, valid and confident application ...