Now showing items 5-8 of 220

    • Campath, calcineurin inhibitor reduction and chronic allograft nephropathy (3C) study: background, rationale, and study protocol 

      Haynes, Richard; Baigent, Colin; Harden, Paul; Landray, Martin; Akyol, Murat; Asderakis, Argiris; Baxter, Alex et al. (2013-05-06)
      Abstract Background Kidney transplantation is the best treatment for patients with end-stage renal failure, but uncertainty remains about the best immunosuppression strategy. Long-term graft survival has not improved ...
    • A structural role for the PHP domain in E. coli DNA polymerase III 

      Barros, Tiago; Guenther, Joel; Kelch, Brian; Anaya, Jordan; Prabhakar, Arjun; O’Donnell, Mike; Kuriyan, John et al. (2013-05-14)
      Abstract Background In addition to the core catalytic machinery, bacterial replicative DNA polymerases contain a Polymerase and Histidinol Phosphatase (PHP) domain whose function is not entirely understood. The PHP domains ...
    • The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing 

      Boudadi, Elsa; Stower, Hannah; Halsall, John A; Rutledge, Charlotte E; Leeb, Martin; Wutz, Anton; O’Neill, Laura P et al. (2013-05-01)
      Abstract Background Histone deacetylase inhibitors (HDACi) cause histone hyperacetylation and H3K4 hypermethylation in various cell types. They find clinical application as anti-epileptics and chemotherapeutic agents, but ...
    • A combination of mutations in AKR1D1 and SKIV2L in a family with severe infantile liver disease 

      Morgan, Neil V; Hartley, Jane L; Setchell, Kenneth DR; Simpson, Michael A; Brown, Rachel; Tee, Louise; Kirkham, Sian et al. (2013-05-16)
      Abstract Infantile cholestatic diseases can be caused by mutations in a number of genes involved in different hepatocyte molecular pathways. Whilst some of the essential pathways have a well understood function, such as ...