The breast cancer genome--a key for better oncology.
Vollan, Hans Kristian Moen
Springer Science and Business Media LLC
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Vollan, H. K. M., & Caldas, C. (2011). The breast cancer genome--a key for better oncology.. BMC Cancer https://doi.org/10.1186/1471-2407-11-501
Molecular classification has added important knowledge to breast cancer biology, but has yet to be implemented as a clinical standard. Full sequencing of breast cancer genomes could potentially refine classification and give a more complete picture of the mutational profile of cancer and thus aid therapy decisions. Future treatment guidelines must be based on the knowledge derived from histopathological sub-classification of tumors, but with added information from genomic signatures when properly clinically validated. The objective of this article is to give some background on molecular classification, the potential of next generation sequencing, and to outline how this information could be implemented in the clinic.
External DOI: https://doi.org/10.1186/1471-2407-11-501
This record's URL: http://www.dspace.cam.ac.uk/handle/1810/241269
Rights Holder: Vollan et al.; licensee BioMed Central Ltd.