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dc.contributor.authorMulligan, Anna Marieen
dc.contributor.authorCouch, Fergus Jen
dc.contributor.authorBarrowdale, Danielen
dc.contributor.authorDomchek, Susan Men
dc.contributor.authorEccles, Dianaen
dc.contributor.authorNevanlinna, Helien
dc.contributor.authorRamus, Susan Jen
dc.contributor.authorRobson, Marken
dc.contributor.authorSherman, Marken
dc.contributor.authorSpurdle, Amanda Ben
dc.contributor.authorWappenschmidt, Barbaraen
dc.contributor.authorAntoniou, Antonisen
dc.contributor.authorFamily, Registry Breast Canceren
dc.contributor.authorEmbrace,en
dc.contributor.authorCollaborators, GEMO Studyen
dc.contributor.authorHebon,en
dc.contributor.authorNetwork, Ontario Cancer Geneticsen
dc.contributor.authorSwe-brca,en
dc.contributor.authorCimba,en
dc.contributor.authorOsorio, Anaen
dc.contributor.authorMunoz-Repeto, Ivanen
dc.contributor.authorCoupier, Isabelleen
dc.contributor.authorDuran, Mercedesen
dc.contributor.authorGodino, Javieren
dc.contributor.authorPertesi, Maroulioen
dc.contributor.authorBenitez, Javieren
dc.contributor.authorPeterlongo, Paoloen
dc.contributor.authorManoukian, Siranoushen
dc.contributor.authorPeissel, Bernarden
dc.contributor.authorZaffaroni, Danielaen
dc.contributor.authorCattaneo, Elisaen
dc.contributor.authorBonanni, Bernardoen
dc.contributor.authorLebrun, Marineen
dc.contributor.authorViel, Alessandraen
dc.contributor.authorPasini, Barbaraen
dc.contributor.authorPapi, Lauraen
dc.contributor.authorOttini, Lauraen
dc.contributor.authorSavarese, Antonellaen
dc.contributor.authorBernard, Lorisen
dc.contributor.authorRadice, Paoloen
dc.contributor.authorHamann, Uteen
dc.contributor.authorVerheus, Martijnen
dc.contributor.authorMeijers-Heijboer, Hanne EJen
dc.contributor.authorKientz, Carolineen
dc.contributor.authorWijnen, Juulen
dc.contributor.authorGomez, Garcia Encarna Ben
dc.contributor.authorNelen, Marcel Ren
dc.contributor.authorKets, C Marleenen
dc.contributor.authorSeynaeve, Carolineen
dc.contributor.authorTilanus-Linthorst, Madeleine MAen
dc.contributor.authorvan, der Luijt Rob Ben
dc.contributor.authorvan, Os Theo Aen
dc.contributor.authorRookus, Mattien
dc.contributor.authorFrost, Debraen
dc.contributor.authorLongy, Michelen
dc.contributor.authorJones, J Louiseen
dc.contributor.authorEvans, D Garethen
dc.contributor.authorLalloo, Fionaen
dc.contributor.authorEeles, Rosen
dc.contributor.authorIzatt, Louiseen
dc.contributor.authorAdlard, Julianen
dc.contributor.authorDavidson, Rosemarieen
dc.contributor.authorCook, Jackieen
dc.contributor.authorDonaldson, Alanen
dc.contributor.authorDorkins, Huwen
dc.contributor.authorSevenet, Nicolasen
dc.contributor.authorGregory, Helenen
dc.contributor.authorEason, Jacquelineen
dc.contributor.authorHoughton, Catherineen
dc.contributor.authorBarwell, Julianen
dc.contributor.authorSide, Lucy Een
dc.contributor.authorMcCann, Emmaen
dc.contributor.authorMurray, Alexen
dc.contributor.authorPeock, Susanen
dc.contributor.authorGodwin, Andrewen
dc.contributor.authorSchmutzler, Rita Ken
dc.contributor.authorStoppa-Lyonnet, Dominiqueen
dc.contributor.authorRhiem, Kerstinen
dc.contributor.authorEngel, Christophen
dc.contributor.authorMeindl, Alfonsen
dc.contributor.authorRuehl, Inaen
dc.contributor.authorArnold, Norberten
dc.contributor.authorNiederacher, Dieteren
dc.contributor.authorSutter, Christianen
dc.contributor.authorDeissler, Helmuten
dc.contributor.authorGadzicki, Dorotheaen
dc.contributor.authorKast, Karinen
dc.contributor.authorIsaacs, Claudineen
dc.contributor.authorPreisler-Adams, Sabineen
dc.contributor.authorVaron-Mateeva, Raymondaen
dc.contributor.authorSchoenbuchner, Inesen
dc.contributor.authorFiebig, Brittaen
dc.contributor.authorHeinritz, Wolframen
dc.contributor.authorSchafer, Dieteren
dc.contributor.authorGevensleben, Heidrunen
dc.contributor.authorCaux-Moncoutier, Virginieen
dc.contributor.authorFassy-Colcombet, Marionen
dc.contributor.authorCornelis, Francoisen
dc.contributor.authorCaldes, Trinidaden
dc.contributor.authorMazoyer, Sylvieen
dc.contributor.authorLeone, Melanieen
dc.contributor.authorBoutry-Kryza, Nadiaen
dc.contributor.authorHardouin, Agnesen
dc.contributor.authorBerthet, Pascalineen
dc.contributor.authorMuller, Danieleen
dc.contributor.authorFricker, Jean-Pierreen
dc.contributor.authorMortemousque, Isabelleen
dc.contributor.authorPujol, Pascalen
dc.contributor.authorde, al Hoya Miguelen
dc.contributor.authorHeikkinen, Tuomasen
dc.contributor.authorLee, Andrewen
dc.contributor.authorAittomaki, Kristiinaen
dc.contributor.authorBlanco, Ignacioen
dc.contributor.authorLazaro, Conxien
dc.contributor.authorBarkardottir, Rosa Ben
dc.contributor.authorSoucy, Pennyen
dc.contributor.authorDumont, Martineen
dc.contributor.authorSimard, Jacquesen
dc.contributor.authorMontagna, Marcoen
dc.contributor.authorTognazzo, Silviaen
dc.contributor.authorD'Andrea, Emmaen
dc.contributor.authorMcGuffog, Lesleyen
dc.contributor.authorFox, Stephenen
dc.contributor.authorYan, Maxen
dc.contributor.authorRebbeck, Timothy Ren
dc.contributor.authorOlopade, Olufunmilayo Ien
dc.contributor.authorWeitzel, Jeffrey Nen
dc.contributor.authorLynch, Henry Ten
dc.contributor.authorGanz, Patricia Aen
dc.contributor.authorTomlinson, Gail Een
dc.contributor.authorWang, Xianshuen
dc.contributor.authorFredericksen, Zacharyen
dc.contributor.authorHealey, Sueen
dc.contributor.authorPankratz, Vernon Sen
dc.contributor.authorLindor, Noralane Men
dc.contributor.authorSzabo, Csilaen
dc.contributor.authorOffit, Kennethen
dc.contributor.authorSakr, Ritaen
dc.contributor.authorGaudet, Miaen
dc.contributor.authorBhatia, Jasmineen
dc.contributor.authorKauff, Noahen
dc.contributor.authorSinger, Christian Fen
dc.contributor.authorTea, Muy-Khengen
dc.contributor.authorSinilnikova, Olga Men
dc.contributor.authorGschwantler-Kaulich, Daphneen
dc.contributor.authorFink-Retter, Annelieseen
dc.contributor.authorMai, Phuong Len
dc.contributor.authorGreene, Mark Hen
dc.contributor.authorImyanitov, Evgenyen
dc.contributor.authorO'Malley, Frances Pen
dc.contributor.authorOzcelik, Hilmien
dc.contributor.authorGlendon, Gordonen
dc.contributor.authorToland, Amanda Een
dc.contributor.authorGerdes, Anne-Marieen
dc.contributor.authorJanavicius, Ramunasen
dc.contributor.authorThomassen, Madsen
dc.contributor.authorKruse, Torben Aen
dc.contributor.authorBirk, Jensen Uffeen
dc.contributor.authorSkytte, Anne-Bineen
dc.contributor.authorCaligo, Maria Aen
dc.contributor.authorSoller, Mariaen
dc.contributor.authorHenriksson, Karinen
dc.contributor.authorvon, Wachenfeldt Annaen
dc.contributor.authorArver, Britaen
dc.contributor.authorStenmark-Askmalm, Marieen
dc.contributor.authorHansen, Thomas VOen
dc.contributor.authorKarlsson, Peren
dc.contributor.authorDing, Yuan Chunen
dc.contributor.authorNeuhausen, Susan Len
dc.contributor.authorBeattie, Maryen
dc.contributor.authorPharoah, Paulen
dc.contributor.authorMoysich, Kirsten Ben
dc.contributor.authorNathanson, Katherine Len
dc.contributor.authorKarlan, Beth Yen
dc.contributor.authorGross, Jennyen
dc.contributor.authorJohn, Esther Men
dc.contributor.authorNielsen, Finn Cen
dc.contributor.authorDaly, Mary Ben
dc.contributor.authorBuys, Saundra Men
dc.contributor.authorSouthey, Melissa Cen
dc.contributor.authorHopper, John Len
dc.contributor.authorTerry, Mary Bethen
dc.contributor.authorChung, Wendyen
dc.contributor.authorMiron, Alexander Fen
dc.contributor.authorGoldgar, Daviden
dc.contributor.authorChenevix-Trench, Georgiaen
dc.contributor.authorEaston, Douglasen
dc.contributor.authorEjlertsen, Benten
dc.contributor.authorAndrulis, Irene Len
dc.date.accessioned2012-02-23T06:09:27Z
dc.date.available2012-02-23T06:09:27Z
dc.date.issued2011-11-02en
dc.identifier.issn1465-542X
dc.identifier.urihttp://www.dspace.cam.ac.uk/handle/1810/241605
dc.description.abstractAbstract Introduction Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour. Methods We used genotype data on up to 11,421 BRCA1 and 7,080 BRCA2 carriers, of whom 4,310 had been affected with breast cancer and had information on either ER or PR status of the tumour, to assess the associations of 12 loci with breast cancer tumour characteristics. Associations were evaluated using a retrospective cohort approach. Results The results suggested stronger associations with ER-positive breast cancer than ER-negative for 11 loci in both BRCA1 and BRCA2 carriers. Among BRCA1 carriers, single nucleotide polymorphism (SNP) rs2981582 (FGFR2) exhibited the biggest difference based on ER status (per-allele hazard ratio (HR) for ER-positive = 1.35, 95% CI: 1.17 to 1.56 vs HR = 0.91, 95% CI: 0.85 to 0.98 for ER-negative, P-heterogeneity = 6.5 × 10-6). In contrast, SNP rs2046210 at 6q25.1 near ESR1 was primarily associated with ER-negative breast cancer risk for both BRCA1 and BRCA2 carriers. In BRCA2 carriers, SNPs in FGFR2, TOX3, LSP1, SLC4A7/NEK10, 5p12, 2q35, and 1p11.2 were significantly associated with ER-positive but not ER-negative disease. Similar results were observed when differentiating breast cancer cases by PR status. Conclusions The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumour subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers.
dc.titleCommon breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.en
dc.typeArticle
dc.date.updated2012-02-23T06:09:27Z
dc.description.versionRIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.en
dc.language.rfc3066en
dc.rights.holderMulligan et al.; licensee BioMed Central Ltd.
prism.publicationDate2011en
dcterms.dateAccepted2011-11-02en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2011-11-02en
dc.contributor.orcidAntoniou, Antonis [0000-0001-9223-3116]
dc.contributor.orcidLee, Andrew [0000-0003-0677-0252]
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.contributor.orcidEaston, Douglas [0000-0003-2444-3247]
dc.identifier.eissn1465-542X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idNational Cancer Institute (R01CA128978)


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