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dc.contributor.authorLuke, Amyen
dc.contributor.authorBovet, Pascalen
dc.contributor.authorForrester, Terrence Een
dc.contributor.authorLambert, Estelle Ven
dc.contributor.authorPlange-Rhule, Jacoben
dc.contributor.authorSchoeller, Dale Aen
dc.contributor.authorDugas, Lara Ren
dc.contributor.authorDurazo-Arvizu, Ramon Aen
dc.contributor.authorShoham, Daviden
dc.contributor.authorCooper, Richard Sen
dc.contributor.authorBrage, Sorenen
dc.contributor.authorEkelund, Ulfen
dc.contributor.authorSteyn, Neliaen
dc.date.accessioned2012-03-08T20:09:31Z
dc.date.available2012-03-08T20:09:31Z
dc.date.issued2011-12-14en
dc.identifier.issn1471-2458
dc.identifier.urihttp://www.dspace.cam.ac.uk/handle/1810/241762
dc.description.abstractAbstract Background The prevalence of obesity has increased in societies of all socio-cultural backgrounds. To date, guidelines set forward to prevent obesity have universally emphasized optimal levels of physical activity. However there are few empirical data to support the assertion that low levels of energy expenditure in activity is a causal factor in the current obesity epidemic are very limited. Methods/Design The Modeling the Epidemiologic Transition Study (METS) is a cohort study designed to assess the association between physical activity levels and relative weight, weight gain and diabetes and cardiovascular disease risk in five population-based samples at different stages of economic development. Twenty-five hundred young adults, ages 25-45, were enrolled in the study; 500 from sites in Ghana, South Africa, Seychelles, Jamaica and the United States. At baseline, physical activity levels were assessed using accelerometry and a questionnaire in all participants and by doubly labeled water in a subsample of 75 per site. We assessed dietary intake using two separate 24-hour recalls, body composition using bioelectrical impedance analysis, and health history, social and economic indicators by questionnaire. Blood pressure was measured and blood samples collected for measurement of lipids, glucose, insulin and adipokines. Full examination including physical activity using accelerometry, anthropometric data and fasting glucose will take place at 12 and 24 months. The distribution of the main variables and the associations between physical activity, independent of energy intake, glucose metabolism and anthropometric measures will be assessed using cross-section and longitudinal analysis within and between sites. Discussion METS will provide insight on the relative contribution of physical activity and diet to excess weight, age-related weight gain and incident glucose impairment in five populations' samples of young adults at different stages of economic development. These data should be useful for the development of empirically-based public health policy aimed at the prevention of obesity and associated chronic diseases.
dc.languageEnglishen
dc.language.isoen
dc.titleProtocol for the modeling the epidemiologic transition study: a longitudinal observational study of energy balance and change in body weight, diabetes and cardiovascular disease risken
dc.typeArticle
dc.date.updated2012-03-08T20:09:32Z
dc.description.versionRIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.en
dc.rights.holderLuke et al.; licensee BioMed Central Ltd.
prism.publicationDate2011en
dcterms.dateAccepted2011-12-14en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2011-12-14en
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
dc.identifier.eissn1471-2458
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/3)


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