Show simple item record

dc.contributor.authorGkoutos, Georgios Ven
dc.contributor.authorHoehndorf, Roberten
dc.date.accessioned2012-09-21T11:06:14Z
dc.date.available2012-09-21T11:06:14Z
dc.date.issued2012-09-21en
dc.identifier.issn2041-1480
dc.identifier.urihttp://www.dspace.cam.ac.uk/handle/1810/243760
dc.description.abstractAbstract Ontologies are widely used in the biomedical community for annotation and integration of databases. Formal definitions can relate classes from different ontologies and thereby integrate data across different levels of granularity, domains and species. We have applied this methodology to the Ascomycete Phenotype Ontology (APO), enabling the reuse of various orthogonal ontologies and we have converted the phenotype associated data found in the SGD following our proposed patterns. We have integrated the resulting data in the cross-species phenotype network PhenomeNET, and we make both the cross-species integration of yeast phenotypes and a similarity-based comparison of yeast phenotypes across species available in the PhenomeBrowser. Furthermore, we utilize our definitions and the yeast phenotype annotations to suggest novel functional annotations of gene products in yeast.
dc.languageEnglishen
dc.language.isoen
dc.titleOntology-based cross-species integration and analysis of Saccharomyces cerevisiae phenotypesen
dc.typeArticle
dc.date.updated2012-09-21T11:06:15Z
dc.description.versionRIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.en
dc.rights.holderGeorgios V Gkoutos et al.; licensee BioMed Central Ltd.
prism.publicationDate2012en
rioxxterms.versionofrecord10.1186/2041-1480-3-S2-S6en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2012-09-21en
dc.identifier.eissn2041-1480
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idNational Human Genome Research Institute (NHGRI) (R01HG004838)
pubs.funder-project-idEC FP7 CP (248502)


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record