A metadata-aware application for remote scoring and exchange of tissue microarray images
Authors
Morris, Lorna
Tsui, Andrew
Crichton, Charles
Harris, Steve
Maccallum, Peter H
Howat, William J
Davies, Jim
Publication Date
2013-05-01ISSN
1471-2105
Language
English
Type
Article
Metadata
Show full item recordCitation
Morris, L., Tsui, A., Crichton, C., Harris, S., Maccallum, P. H., Howat, W. J., Davies, J., et al. (2013). A metadata-aware application for remote scoring and exchange of tissue microarray images. https://doi.org/10.1186/1471-2105-14-147
Abstract
Abstract Background The use of tissue microarrays (TMA) and advances in digital scanning microscopy has enabled the collection of thousands of tissue images. There is a need for software tools to annotate, query and share this data amongst researchers in different physical locations. Results We have developed an open source web-based application for remote scoring of TMA images, which exploits the value of Microsoft Silverlight Deep Zoom to provide a intuitive interface for zooming and panning around digital images. We use and extend existing XML-based standards to ensure that the data collected can be archived and that our system is interoperable with other standards-compliant systems. Conclusion The application has been used for multi-centre scoring of TMA slides composed of tissues from several Phase III breast cancer trials and ten different studies participating in the International Breast Cancer Association Consortium (BCAC). The system has enabled researchers to simultaneously score large collections of TMA and export the standardised data to integrate with pathological and clinical outcome data, thereby facilitating biomarker discovery.
Sponsorship
MRC (G0300648)
Identifiers
External DOI: https://doi.org/10.1186/1471-2105-14-147
This record's URL: http://www.dspace.cam.ac.uk/handle/1810/244600
Rights
Rights Holder: Lorna Morris et al.; licensee BioMed Central Ltd.
Licence:
http://www.rioxx.net/licenses/all-rights-reserved