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The mechanical control of nervous system development.


Type

Article

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Authors

Abstract

The development of the nervous system has so far, to a large extent, been considered in the context of biochemistry, molecular biology and genetics. However, there is growing evidence that many biological systems also integrate mechanical information when making decisions during differentiation, growth, proliferation, migration and general function. Based on recent findings, I hypothesize that several steps during nervous system development, including neural progenitor cell differentiation, neuronal migration, axon extension and the folding of the brain, rely on or are even driven by mechanical cues and forces.

Description

Keywords

Brain folding, Force, Mechanics, Mechanosensitivity, Mechanotaxis, Mechanotransduction, Stiffness, Tension, Animals, Biomechanical Phenomena, Brain, Cell Movement, Mechanotransduction, Cellular, Models, Neurological, Nerve Net, Nervous System, Nervous System Physiological Phenomena, Neurogenesis

Journal Title

Development

Conference Name

Journal ISSN

0950-1991
1477-9129

Volume Title

140

Publisher

The Company of Biologists
Sponsorship
Medical Research Council (G1100312)
This work was supported by the Medical Research Council