Now showing items 1-4 of 30837

    • Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases. 

      Li, Yong; Cheng, Yurong; Consolato, Francesco; Schiano, Guglielmo; Chong, Michael R; Pietzner, Maik; Nguyen, Ngoc Quynh H et al. (American Society for Clinical Investigation, 2022-05-23)
      Uromodulin (UMOD) is a major risk gene for monogenic and complex forms of kidney disease. The encoded kidney-specific protein uromodulin is highly abundant in urine and related to chronic kidney disease, hypertension, and ...
    • A chiral phosphazane reagent strategy for the determination of enantiomeric excess of amines. 

      Peel, Andrew J; Terzopoulos, Alexandros; Jethwa, Rajesh; Choudhury, Dipanjana; Niu, Hao-Che; Bond, Andrew; Slaughter, Jonathan et al. (Royal Society of Chemistry (RSC), 2022-05-11)
      Methods for measuring enantiomeric excess (ee) of organic molecules by NMR spectroscopy provide rapid analysis using a standard technique that is readily available. Commonly this is accomplished by chiral derivatisation ...
    • Clathrin adaptor AP-1-mediated Golgi export of amyloid precursor protein is crucial for the production of neurotoxic amyloid fragments. 

      Januário, Yunan C; Eden, Jessica; de Oliveira, Luan S; De Pace, Raffaella; Tavares, Lucas A; da Silva-Januário, Mara E; Apolloni, Vinícius B et al. (Elsevier BV, 2022-06-23)
      One of the hallmarks of Alzheimer's disease (AD) is the accumulation of toxic amyloid-β (Aβ) peptides in extracellular plaques. The direct precursor of Aβ is the carboxyl-terminal fragment (CTFβ or C99) of the amyloid ...
    • NEOLITHIC TRACK SITES FROM FORMBY POINT, ENGLAND: NEW DATA AND INSIGHTS 

      Wiseman, Ashleigh; Vicari, Deborah; Belvedere, Matteo; De Groote, Isabelle
      Formby Point, England is a well-documented exposure site in which marine erosion has regularly exposed Neolithic human trackways along the coastline since the 1980s. We report here the discovery of an additional 17 trackways ...