Now showing items 1-5 of 5

    • Circulating Tumour DNA in Localised Urological Cancers 

      Patel, Keval Mahendra (2017-11-02)
      There is a need for informative biomarkers in localised urological cancers. At present, no method can accurately distinguish between indolent and aggressive prostate cancers, and men often require repeated biopsies. Patients ...
    • Estrogen receptor beta modulates prostate carcinogenesis 

      Nelson, Adam William (2017-10-01)
      Prostate cancer (PC) is characterised by dependence upon androgen receptor (AR) as its driving oncogene. When organ-confined, radical treatment can be curative, however there is no cure for advanced, castration-resistant ...
    • Functional characterisation of driver events in ovarian clear cell carcinoma 

      Gounaris, Ioannis (2014-11-11)
      Ovarian clear cell carcinoma (OCCC) is a distinct subtype of epithelial ovarian cancer (EOC) characterised by glycogen accumulation. Frequently arising within endometriotic cysts, it can be conceived as an ectopic ...
    • Latent feature models and non-invasive clonal reconstruction 

      Marass, Francesco (2017-07-22)
      Intratumoural heterogeneity complicates the molecular interpretation of biopsies, as multiple distinct tumour genomes are sampled and analysed at once. Ignoring the presence of these populations can lead to erroneous ...
    • Machine Learning Methods for Cancer Immunology 

      Chlon, Leon (2017-11-01)
      Tumours are highly heterogeneous collections of tissues characterised by a repertoire of heavily mutated and rapidly proliferating cells. Evading immune destruction is a fundamental hallmark of cancer, and elucidating the ...