Show simple item record

dc.contributor.authorLi, Cen
dc.contributor.authorZeitler, Axelen
dc.contributor.authorDong, Yen
dc.contributor.authorShen, Y-Cen
dc.date.accessioned2014-05-16T09:04:59Z
dc.date.available2014-05-16T09:04:59Z
dc.date.issued2014-01en
dc.identifier.citationLi, C., Zeitler, J. A., Dong, Y. and Shen, Y.-C. (2014), Non-Destructive Evaluation of Polymer Coating Structures on Pharmaceutical Pellets Using Full-Field Optical Coherence Tomography. J. Pharm. Sci., 103: 161-166. doi: 10.1002/jps.23764en
dc.identifier.issn0022-3549
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/245272
dc.description.abstractFull field optical coherence tomography (FF-OCT) using a conventional LED light source and a CMOS camera has been developed for characterising coatings on small pellet samples. A set of en-face images covering an area of 700µm x 700µm were taken over a depth range of 166 µm. The three-dimensional structural information, such as the coating thickness and uniformity, was subsequently obtained by analysis of the recorded en-face images. Drug loaded pharmaceutical sustained release pellets with two coating layers and of a sub-millimetre diameter were studied to demonstrate the usefulness of the developed system. We have shown that both coatings can be clearly resolved and the thickness was determined to be 40 µm and 50 µm for the outer and inner coating layers, respectively. It was also found that the outer coating layer is relatively uniform whilst the inner coating layer has many particle-like features. X-ray Computed Microtomography (X?CT) measurements carried out on the same pellet sample confirmed all these findings. The presented FF-OCT approach is inexpensive and has better spatial resolution compared to other non-destructive analysis techniques such as terahertz pulsed imaging, and is thus considered advantageous for the quantitative analysis of thin coatings on small pellet samples.
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.subjectoptical coherency tomography (OCT)en
dc.subjectimaging methodsen
dc.subjectcoatingen
dc.subjectpelleten
dc.subjectexcipientsen
dc.titleNondestructive evaluation of Polymer Coating Structures on Pharmaceutical Pellets using Full Field Optical Coherence Tomographyen
dc.typeArticle
dc.description.versionThis is the pre-peer reviewed version of the following article: Li, C., Zeitler, J. A., Dong, Y. and Shen, Y.-C. (2014), Non-Destructive Evaluation of Polymer Coating Structures on Pharmaceutical Pellets Using Full-Field Optical Coherence Tomography. J. Pharm. Sci., 103: 161-166. doi: 10.1002/jps.23764, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/jps.23764/abstracten
prism.publicationDate2014en
prism.publicationNameJournal of Pharmaceutical Sciencesen
dcterms.dateAccepted2013-10-10en
rioxxterms.versionofrecord10.1002/jps.23764en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-01en
dc.contributor.orcidZeitler, Axel [0000-0002-4958-0582]
dc.identifier.eissn1520-6017
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2015-01-31


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record