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dc.contributor.authorBekinschtein, Pedroen
dc.contributor.authorKent, Brianne Aen
dc.contributor.authorOomen, Charlotte Aen
dc.contributor.authorClemenson, Gregory Den
dc.contributor.authorGage, Fred Hen
dc.contributor.authorSaksida, Lisaen
dc.contributor.authorBussey, Timothyen
dc.date.accessioned2014-07-03T11:11:48Z
dc.date.available2014-07-03T11:11:48Z
dc.date.issued2014-05-23en
dc.identifier.citationBekinschtein, P., Kent, B. A., Oomen, C. A., Clemenson, G. D., Gage, F. H., Saksida, L. M. and Bussey, T. J. (2014), Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories. Hippocampus. doi: 10.1002/hipo.22304en
dc.identifier.issn1050-9631
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/245365
dc.description.abstractSuccessful memory involves not only remembering information over time but also keeping memories distinct and less confusable. The computational process for making representations of similar input patterns more distinct from each other has been referred to as “pattern separation.” Although adult-born immature neurons have been implicated in this memory feature, the precise role of these neurons and associated molecules in the processing of overlapping memories is unknown. Recently, we found that brain-derived neurotrophic factor (BDNF) in the dentate gyrus is required for the encoding/consolidation of overlapping memories. In this study, we provide evidence that consolidation of these “pattern-separated” memories requires the action of BDNF on immature neurons specifically. © 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc.
dc.description.sponsorshipThe Biotechnology and Biological Sciences Research Council . Grant Number: BB/G019002/1 The Innovative Medicine Initiative Joint Undertaking . Grant Number: 115008 The European Union's Seventh Framework Programme . Grant Number: FP7/2007-2013 The James S. McDonnell Foundation, Mather's Foundation, NIMH, Ellison Foundation, NINDS, NIMH, NIA, JPB Foundation
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.subjectmemory consolidationen
dc.subjectdentate gyrusen
dc.subjectBDNFen
dc.subjectneurogenesisen
dc.titleBrain-Derived Neurotrophic Factor Interacts with Adult-Born Immature Cells in the Dentate Gyrus During Consolidation of Overlapping Memoriesen
dc.typeConference Object
dc.description.versionThis is the final published version, which can also be viewed online at: http://onlinelibrary.wiley.com/doi/10.1002/hipo.22304/fullen
prism.publicationDate2014en
prism.publicationNameHippocampusen
dc.rioxxterms.funderBBSRC
dc.rioxxterms.projectidBB/G019002/1
dcterms.dateAccepted2014-05-09en
rioxxterms.versionofrecord10.1002/hipo.22304en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-05-23en
dc.identifier.eissn1098-1063
rioxxterms.typeConference Paper/Proceeding/Abstracten
pubs.funder-project-idBBSRC (BB/G019002/1)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (G0001354)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales