Lineage selection and plasticity in the intestinal crypt.
Curr Opin Cell Biol
MetadataShow full item record
Philpott, A., & Winton, D. (2014). Lineage selection and plasticity in the intestinal crypt.. Curr Opin Cell Biol, 31 39-45. https://doi.org/10.1016/j.ceb.2014.07.002
We know more about the repertoire of cellular behaviours that define the stem and progenitor cells maintaining the intestinal epithelium than any other renewing tissue. Highly dynamic and stochastic processes define cell renewal. Historically the commitment step in differentiation is viewed as a ratchet, irreversibly promoting a given fate and corresponding to a programme imposed at the point of cell division. However, the emerging view of intestinal self-renewal is one of plasticity in which a stem cell state is easily reacquired. The pathway mediators of lineage selection are largely known but how they interface within highly dynamic populations to promote different lineages and yet permit plasticity is not. Advances in understanding gene regulation in the nervous system suggest possible mechanisms.
AP was supported by Medical Research Council Research grant MR/K018329/1. DJW is funded by Cancer Research UK.
Medical Research Council (MR/K018329/1)
Cancer Research UK (C14303/A17197)
Embargo Lift Date
External DOI: https://doi.org/10.1016/j.ceb.2014.07.002
This record's URL: https://www.repository.cam.ac.uk/handle/1810/245497
DSpace@Cambridge license, Attribution 2.0 UK: England & Wales, Creative Commons Attribution License 2.0 UK
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/