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dc.contributor.authorPhilpott, Annaen
dc.contributor.authorWinton, Douglasen
dc.date.accessioned2014-07-14T16:19:20Z
dc.date.available2014-07-14T16:19:20Z
dc.date.issued2014-09-15en
dc.identifier.citation(2014) Current Opinion in Cell Biology 31: 39-45
dc.identifier.issn0955-0674
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/245497
dc.description.abstractWe know more about the repertoire of cellular behaviours that define the stem and progenitor cells maintaining the intestinal epithelium than any other renewing tissue. Highly dynamic and stochastic processes define cell renewal. Historically the commitment step in differentiation is viewed as a ratchet, irreversibly promoting a given fate and corresponding to a programme imposed at the point of cell division. However the emerging view of intestinal self-renewal is one of plasticity in which a stem cell state is easily reacquired. The pathway mediators of lineage selection are largely known but how they interface within highly dynamic populations to promote different lineages and yet permit plasticity is not. Advances in understanding gene regulation in the nervous system suggest possible mechanisms.
dc.description.sponsorshipAP was supported by Medical Research Council Research grant MR/K018329/1. DJW is funded by Cancer Research UK.
dc.languageEnglishen
dc.language.isoenen
dc.rightsDSpace@Cambridge license
dc.rightsAttribution 2.0 UK: England & Wales
dc.rightsCreative Commons Attribution License 2.0 UK
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.titleLineage selection and plasticity in the intestinal crypten
dc.typeArticle
dc.description.versionThis is the final published manuscript. It has been published by Elsevier in Current Opinion in Cell Biology here: http://www.sciencedirect.com/science/article/pii/S0955067414000866.en
prism.endingPage45
prism.publicationDate2014en
prism.publicationNameCurrent Opinion in Cell Biologyen
prism.startingPage39
prism.volume31en
dc.rioxxterms.funderMRC
dc.rioxxterms.projectidMR/K018329/1
dc.embargo.liftdate2030-07-08
dc.embargo.terms2030-07-08
dcterms.dateAccepted2014-07-11en
rioxxterms.versionofrecord10.1016/j.ceb.2014.07.002en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-09-15en
dc.contributor.orcidPhilpott, Anna [0000-0003-3789-2463]
dc.contributor.orcidWinton, Douglas [0000-0001-6067-7927]
dc.identifier.eissn1879-0410
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/K018329/1)
pubs.funder-project-idCancer Research UK (C14303_do not transfer)
rioxxterms.freetoread.startdate2030-07-08


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