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dc.contributor.authorPetry, Cliveen
dc.contributor.authorBeardsall, Kathrynen
dc.contributor.authorDunger, Daviden
dc.date.accessioned2014-07-31T14:04:52Z
dc.date.available2014-07-31T14:04:52Z
dc.date.issued2014-08-01en
dc.identifier.citationPetry CJ, Beardsall K, Dunger DB. "The potential impact of the fetal genotype on maternal blood pressure during pregnancy". J Hypertens. 2014 Aug;32(8):1553-61. doi: 10.1097/HJH.0000000000000212
dc.identifier.issn0263-6352
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/245600
dc.description.abstractThe heritability of pregnancy-induced hypertension (encompassing both gestational hypertension and preeclampsia) is around 0.47, suggesting that there is a genetic component to its development. However, the maternal genetic risk variants discovered so far only account for a small proportion of the heritability. Other genetic variants that may affect maternal blood pressure in pregnancy arise from the fetal genome, for example wild-type pregnant mice carrying offspring with Cdkn1c or Stox1 disrupted develop hypertension and proteinuria. In humans, there is a higher risk for preeclampsia in women carrying fetuses with Beckwith–Wiedemann syndrome (including those fetuses with CDKN1C mutations) and a lower risk for women carrying babies with trisomy 21. Other risk may be associated with imprinted fetal growth genes and genes that are highly expressed in the placenta such as GCM1. This article reviews the current state of knowledge linking the fetal genotype with maternal blood pressure in pregnancy.
dc.description.sponsorshipMRC
dc.publisherLippincott Williams & Wilkins
dc.titleThe potential impact of the fetal genotype on maternal blood pressure during pregnancyen
dc.typeArticle
dc.description.versionThis is the Author Accepted Manuscript of Petry CJ, Beardsall K, Dunger DB. "The potential impact of the fetal genotype on maternal blood pressure during pregnancy". published in the Journal of Hypertension. The published version is available at http://dx.doi.org/10.1097/HJH.0000000000000212en
prism.endingPage1561
prism.publicationDate2014en
prism.publicationNameJournal of Hypertensionen
prism.startingPage1553
prism.volume32en
dc.rioxxterms.funderMedical Research Council
dc.rioxxterms.projectidG0500733
dcterms.dateAccepted2014-03-18en
rioxxterms.versionofrecord10.1097/HJH.0000000000000212en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-08-01en
dc.contributor.orcidPetry, Clive [0000-0002-6642-9825]
dc.contributor.orcidBeardsall, Kathryn [0000-0003-3582-183X]
dc.contributor.orcidDunger, David [0000-0002-2566-9304]
dc.identifier.eissn1473-5598
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellbeing of Women (RG1644)
pubs.funder-project-idNational Institute for Health Research ()
pubs.funder-project-idMRC (G0500733)
rioxxterms.freetoread.startdate2015-08-01


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