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Building a flagellum in biological outer space.


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Authors

Evans, Lewis DB 
Hughes, Colin 
Fraser, Gillian M 

Abstract

Flagella, the rotary propellers on the surface of bacteria, present a paradigm for how cells build and operate complex molecular 'nanomachines'. Flagella grow at a constant rate to extend several times the length of the cell, and this is achieved by thousands of secreted structural subunits transiting through a central channel in the lengthening flagellum to incorporate into the nascent structure at the distant extending tip. A great mystery has been how flagella can assemble far outside the cell where there is no conventional energy supply to fuel their growth. Recent work published by Evans et al. [Nature (2013) 504: 287-290], has gone some way towards solving this puzzle, presenting a simple and elegant transit mechanism in which growth is powered by the subunits them selves as they link head-to-tail in a chain that is pulled through the length of the growing structure to the tip. This new mechanism answers an old question and may have resonance in other assembly processes.

Description

Keywords

Type III export, bacterial flagella, cell motility, chain mechanism, rotary nanomachine

Journal Title

Microb Cell

Conference Name

Journal ISSN

2311-2638
2311-2638

Volume Title

1

Publisher

Shared Science Publishers OG
Sponsorship
Wellcome Trust (082895/Z/07/Z)