Facilitated diffusion buffers noise in gene expression.
Change log
Authors
Schoech, Armin P
Zabet, Nicolae Radu
Abstract
Transcription factors perform facilitated diffusion [three-dimensional (3D) diffusion in the cytosol and 1D diffusion on the DNA] when binding to their target sites to regulate gene expression. Here, we investigated the influence of this binding mechanism on the noise in gene expression. Our results showed that, for biologically relevant parameters, the binding process can be represented by a two-state Markov model and that the accelerated target finding due to facilitated diffusion leads to a reduction in both the mRNA and the protein noise.
Description
Keywords
Buffers, Facilitated Diffusion, Gene Expression Regulation, Lac Repressors, Models, Genetic, Transcription Factors
Journal Title
Phys Rev E Stat Nonlin Soft Matter Phys
Conference Name
Journal ISSN
1539-3755
1550-2376
1550-2376
Volume Title
90
Publisher
American Physical Society (APS)
Publisher DOI
Sponsorship
Medical Research Council (G1002110)