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Inside and out: the activities of senescence in cancer.


Type

Article

Change log

Authors

Pérez-Mancera, Pedro A 
Young, Andrew RJ 

Abstract

The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However, this is a disguise that conceals a highly active metabolic cell state with diverse functionality. Both the cell-autonomous and the non-cell-autonomous activities of senescent cells create spatiotemporally dynamic and context-dependent tissue reactions. For example, the senescence-associated secretory phenotype (SASP) provokes not only tumour-suppressive but also tumour-promoting responses. Senescence is now increasingly considered to be an integrated and widespread component that is potentially important for tumour development, tumour suppression and the response to therapy.

Description

Keywords

Animals, Cellular Senescence, Humans, Neoplasms, Precancerous Conditions, Signal Transduction, Tumor Microenvironment

Journal Title

Nat Rev Cancer

Conference Name

Journal ISSN

1474-175X
1474-1768

Volume Title

14

Publisher

Springer Science and Business Media LLC
Sponsorship
Cancer Research UK (C14303/A17197)