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Obesity and FTO: Changing Focus at a Complex Locus.


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Authors

Tung, YC Loraine 
Yeo, Giles SH 
Coll, Anthony P 

Abstract

The fat mass and obesity-associated (FTO) gene was placed center stage when common intronic variants within the gene were robustly associated with human obesity. Murine models of perturbed Fto expression have shown effects on body weight and composition. However, a clear understanding of the link between FTO intronic variants and FTO activity has remained elusive. Two recent reports now indicate that obesity-associated SNPs appear functionally connected not with FTO but with two neighboring genes: IRX3 and RPGRIP1L. Here, we review these new findings and consider the implications for future analysis of GWAS hits.

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Keywords

Animals, Dopamine, Genetic Loci, Genome-Wide Association Study, Humans, Mixed Function Oxygenases, Obesity, Polymorphism, Single Nucleotide

Journal Title

Cell Metab

Conference Name

Journal ISSN

1550-4131
1932-7420

Volume Title

20

Publisher

Elsevier BV
Sponsorship
Medical Research Council (G0600717)
Medical Research Council (MC_UU_12012/1)
Medical Research Council (G0900554)
Medical Research Council (MC_PC_12012)