Show simple item record

dc.contributor.authorTito, Nicholasen
dc.contributor.authorFrenkel, Daanen
dc.date.accessioned2014-09-30T11:26:27Z
dc.date.available2014-09-30T11:26:27Z
dc.date.issued2014-10-09en
dc.identifier.citationMacromolecules 2014, 47 (21), pp 7496–7509. DOI: 10.1021/ma5014918en
dc.identifier.issn0024-9297
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/246073
dc.description.abstractMultivalent polymers are macromolecules containing multiple chemical moieties designed to bind to complementary moieties on a target; for example, a protein with multiple ligands that have affinity for receptors on a cell surface. Though the individual ligand-receptor bonds are often weak, the combinatorial entropy associated with the different possible ligand-receptor pairs leads to a binding transition that can be very sharp with respect to control parameters, such as temperature or surface receptor concentration. We use mean-field self-consistent field theory to study the binding selectivity of multivalent polymers to receptor-coated surfaces. Polymers that have their ligands clustered into a contiguous domain, either located at the chain end or chain midsection, exhibit cooperative surface adsorption and superselectivity when the polymer concentration is low. On the other hand, when the ligands are uniformly spaced along the chain backbone, selectivity is substantially reduced due to the lack of binding cooperativity, and due to crowding of the surface by the inert polymer segments in the chain backbone.
dc.languageEnglishen
dc.language.isoenen
dc.publisherACS
dc.rightsAttribution 2.0 UK: England & Wales
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.titleOptimising the Selectivity of Surface-Adsorbing Multivalent Polymersen
dc.typeArticle
dc.description.versionThis is the final version. It was first published by ACS at http://pubs.acs.org/doi/abs/10.1021/ma5014918.en
prism.endingPage7509
prism.publicationDate2014en
prism.publicationNameMacromoleculesen
prism.startingPage7496
prism.volume47en
dc.rioxxterms.funderEngineering and Physical Sciences Research Council
dc.rioxxterms.funderERC
dc.rioxxterms.projectidEPSRC: EP/I001352/1
dc.rioxxterms.projectid227758
rioxxterms.versionofrecord10.1021/ma5014918en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-10-09en
dc.contributor.orcidFrenkel, Daan [0000-0002-6362-2021]
dc.identifier.eissn1520-5835
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (EP/I001352/1)
pubs.funder-project-idEuropean Research Council (227758)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales