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dc.contributor.authorCooper, Andrewen
dc.contributor.authorSharp, Stephenen
dc.contributor.authorLuben, Roberten
dc.contributor.authorKhaw, Kay-Teeen
dc.contributor.authorWareham, Nicholasen
dc.contributor.authorForouhi, Nitaen
dc.date.accessioned2014-10-09T10:43:09Z
dc.date.available2014-10-09T10:43:09Z
dc.date.issued2014en
dc.identifier.citationCooper et al. European Journal of Clinical Nutrition (2014) Vol. 69, pp. 449–454. DOI: 10.1038/ejcn.2014.246en
dc.identifier.issn0954-3007
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/246148
dc.description.abstractBackground/Objectives: Biomarkers for a mixed fruit and vegetable (FV) diet are needed to provide a better understanding of the association between FV intake and type 2 diabetes. We aimed to examine the prospective association between a composite score comprised of three biomarkers of FV intake in free-living populations and incident diabetes. Subjects/Methods: A total of 318 incident diabetes cases and 926 controls from the EPIC-Norfolk study aged 40-79 years at baseline (1993-1997) completed 7-day food diaries (7DD) and had plasma vitamin C and carotenoid measures. A composite biomarker score (CB-score) comprising the sum of plasma vitamin C, beta-carotene and lutein was derived. Odds ratios (OR) and 95% confidence intervals for incident diabetes were estimated using multivariable logistic regression. Results: A strong inverse association was found between the CB-score and incident diabetes. The OR (95% CI) of diabetes comparing quartiles Q2, Q3 and Q4 of the CB-score with Q1 (reference category) were 0.70 (0.49, 1.00), 0.34 (0.23, 0.52) and 0.19 (0.12, 0.32), respectively, and 0.49 (0.40, 0.58) per SD change in CB-score in a model adjusted for demographic and lifestyle factors. The association was marginally attenuated after additionally adjusting for BMI and waist circumference (0.60 (0.49, 0.74) per SD change in CB-score). Conclusions: A combination of biomarkers representing the intake of a mixed FV diet was strongly inversely associated with incident diabetes. These findings provide further support for measuring dietary biomarkers in studies of diet-disease associations and highlight the importance of consuming FV for the prevention of diabetes.
dc.description.sponsorshipThe EPIC Norfolk study is supported by programme grants from the Medical Research Council UK and Cancer Research UK. The sponsors did not participate in the design or conduct of this study; in the collection, management, analysis, or interpretation of data; in the writing of the manuscript; or in the preparation, review, approval, or decision to submit this manuscript for publication. We acknowledge support from the MRC Epidemiology Unit (MC_UU_12015/5).
dc.languageEnglishen
dc.language.isoenen
dc.publisherNature Publishing Group
dc.titleThe association between a biomarker score for fruit and vegetable intake and incident type 2 diabetes: the EPIC-Norfolk studyen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from NPG via http://dx.doi.org/10.1038/ejcn.2014.246en
prism.endingPage454
prism.publicationDate2014en
prism.publicationNameEuropean Journal of Clinical Nutritionen
prism.startingPage449
prism.volume69en
dc.rioxxterms.funderMRC
dc.rioxxterms.funderCRUK
dc.rioxxterms.projectidMC_UU_12015/5
dcterms.dateAccepted2014-10-03en
rioxxterms.versionofrecord10.1038/ejcn.2014.246en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014en
dc.contributor.orcidSharp, Stephen [0000-0003-2375-1440]
dc.contributor.orcidLuben, Robert [0000-0002-5088-6343]
dc.contributor.orcidKhaw, Kay-Tee [0000-0002-8802-2903]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidForouhi, Nita [0000-0002-5041-248X]
dc.identifier.eissn1476-5640
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/5)
pubs.funder-project-idMRC (G1000143)
pubs.funder-project-idMRC (MC_UU_12015/1)
pubs.funder-project-idMRC (MC_UU_12015/4)
pubs.funder-project-idMRC (G0401527)
pubs.funder-project-idMedical Research Council (MC_U106179471)
pubs.funder-project-idMedical Research Council (MC_U106179474)


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