Primoridal germ cell specification: a context-dependent cellular differentiation event
Philosophical Transactions of the Royal Society B
Royal Society Publishing
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Günesdogan, U., Magnúsdóttir, E., & Surani, A. (2014). Primoridal germ cell specification: a context-dependent cellular differentiation event. Philosophical Transactions of the Royal Society B, 369 (20130543)https://doi.org/10.1098/rstb.2013.0543
During embryonic development, the foundation of the germline is laid by the specification of primordial germ cells (PGCs) from the postimplantation epiblast via BMP and WNT signalling. While the majority of epiblast cells undergo differentiation towards somatic cell lineages, PGCs initiate a unique cellular programme driven by the cooperation of the transcription factors BLIMP1, PRDM14 and AP2g. These factors synergistically suppress the ongoing somatic differentiation and drive the re-expression of pluripotency and germ cell-specific genes accompanied by global epigenetic changes. However, an unresolved question is how postimplantation epiblast cells acquire the developmental competence for the PGC fate downstream of BMP/WNT signalling. One emerging concept is that transcriptional enhancers might play a central role in the establishment of developmental competence and the execution of cell fate determination. Here, we discuss recent advances on the specification and reprogramming of PGCs thereby highlighting the concept of enhancer function.
U.G. is supported by a Marie Curie Intra-European fellowship. E.M. is supported by the Icelandic Research Fund. M.A.S. is supported by the Wellcome Trust (WT096738).
Wellcome Trust (092096/Z/10/Z)
External DOI: https://doi.org/10.1098/rstb.2013.0543
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246160
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/
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