Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute
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10.1038/s41588-018-0114-z DO
The H3K27 lysine-specific demethylase UTX is targeted by loss-of-function mutations in multiple cancers. Here, we demonstrate that UTX suppresses myeloid leukemogenesis through non-catalytic functions, a property shared ... -
Association of subchondral bone texture on magnetic resonance imaging with radiographic knee osteoarthritis progression: data from the Osteoarthritis Initiative Bone Ancillary Study.
(Springer Nature, 2018-05-02)Objectives To assess whether initial or 12-18 month change in magnetic resonance imaging (MRI) subchondral bone texture is predictive of radiographic knee osteoarthritis (OA) progression over 36 months. Methods This was a ... -
Origin and dynamics of oligodendrocytes in the developing brain: Implications for perinatal white matter injury.
(Wiley, 2018-02)Infants born prematurely are at high risk to develop white matter injury (WMI), due to exposure to hypoxic and/or inflammatory insults. Such perinatal insults negatively impact the maturation of oligodendrocytes (OLs), ... -
Contributions of BMPR2 Mutations and Extrinsic Factors to Cellular Phenotypes of Pulmonary Arterial Hypertension Revealed by iPSC Modeling.
(2018-03-16)Reduced bone morphogenetic protein receptor 2 (BMPR2) signaling is central to the pathobiology of pulmonary arterial hypertension (PAH). However, the reduced penetrance of BMPR2 mutations in families suggests that other ...
