Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute

Recent Submissions

  • Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline. 

    Lupo, Giuseppe; Nisi, Paola S; Esteve, Pilar; Paul, Yu-Lee; Novo, Clara Lopes; Sidders, Ben; Khan, Muhammad A et al. (Elsevier, 2018-03-05)
    Adult neurogenesis declines with aging due to the depletion and functional impairment of neural 3 stem/progenitor cells (NSPCs). An improved understanding of the underlying mechanisms that 4 drive age-associated neurogenic ...

  • Glioblastoma stem cells respond to differentiation cues but fail to undergo commitment and terminal cell cycle arrest 

    Carén, H; Stricker, SH; Bulstrode, H; Gagrica, S; Johnstone, E; Bartlett, TE; Feber, A et al. (Elsevier (Cell Press), 2015-11-10)
    Glioblastoma (GBM) is an aggressive brain tumor whose growth is driven by stemcell-like cells. BMP signaling triggers cell-cycle exit and differentiation of GBM stem cells (GSCs) and, therefore, might have therapeutic ...

  • Myc depletion induces a pluripotent dormant state mimicking diapause 

    Scognamiglio, R; Cabezas-Wallscheid, N; Thier, MC; Altamura, S; Reyes, A; Prendergast, Á; Baumgärtner, D et al. (Elsevier (Cell Press), 2016-02-11)
    Mouse embryonic stem cells (ESCs) are maintained in a naive ground state of pluripotency in the presence of MEK and GSK3 inhibitors. Here, we show that ground-state ESCs express low Myc levels. Deletion of both c-myc and ...

  • Chromatin Remodelling Proteins and Cell Fate Decisions in Mammalian Preimplantation Development. 

    Miller, Anne-Louise; Hendrich, Brian (Springer Nature, 2018-01)
    The very first cell divisions in mammalian embryogenesis produce a ball of cells, each with the potential to form any cell in the developing embryo or placenta. At some point the embryo produces enough cells that some are ...

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