Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute
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(Elsevier, 2018-06)The means and timing by which mutations become fixed in the human colonic epithelium was investigated by visualizing somatic clones and mathematical inference. Fixation requires two sequential steps. First, one of approximately ...
Thromopoietin signaling to chromatin elicits rapid and pervasive epigenome remodeling within poised chromatin architectures. Thrombopoietin (TPO) is a critical cytokine regulating hematopoietic stem cell maintenance and differentiation into the megakaryocytic lineage. However, the transcriptional and chromatin dynamics elicited by TPO signaling ...