Recent Submissions

  • Formative pluripotency: the executive phase in a developmental continuum. 

    Smith, A (The Company of Biologists, 2017-02-01)
    The regulative capability of single cells to give rise to all primary embryonic lineages is termed pluripotency. Observations of fluctuating gene expression and phenotypic heterogeneity in vitro have fostered a conception ...
  • One-step generation of conditional and reversible gene knockouts 

    Andersson-Rolf, A; Mustata, RC; Merenda, A; Kim, J; Perera, S; Grego, T; Andrews, K et al. (Nature Publishing Group, 2017-03-01)
    Loss-of-function studies are key for investigating gene function, and CRISPR technology has made genome editing widely accessible in model organisms and cells. However, conditional gene inactivation in diploid cells is ...
  • Primate embryogenesis predicts the hallmarks of human naïve pluripotency 

    Boroviak, T; Nichols, J (The Company of Biologists, 2017-01-15)
    Naïve pluripotent mouse embryonic stem cells (ESCs) resemble the preimplantation epiblast and efficiently contribute to chimaeras. Primate ESCs correspond to the postimplantation embryo and fail to resume development in ...
  • Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility 

    Flores, JV; Cordero-Espinoza, L; Oeztuerk-Winder, F; Andersson-Rolf, A; Selmi, T; Blanco, S; Tailor, J et al. (Elsevier, 2017-01-10)
    Loss-of-function mutations in the cytosine-5 RNA methylase NSUN2 cause neurodevelopmental disorders in humans, yet the underlying cellular processes leading to the symptoms that include microcephaly remain unclear. Here, ...

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