Recent Submissions

  • Blood: Education for stem cells 

    Guibentif, C; Göttgens, B (Nature Publishing Group, 2017-05-25)
    Haematopoietic stem cells give rise to all lineages of blood cell, and their production $\textit{in vitro}$ has been a long-sought goal of stem-cell biology. Two groups now achieve this feat through different means.
  • Reconstruction of the murine extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids 

    Vallier, L; Sampaziotis, F; Justin, AW; Tysoe, OC; Sawiak, S; Cardoso-de-Brito, M; Ortmann, D et al.
    Treatment of common bile duct disorders such as biliary atresia or ischaemic strictures is limited to liver transplantation or hepatojejunostomy due to the lack of suitable tissue for surgical reconstruction. Here, we ...
  • A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2 

    Zhou, J; Tien, A-C; Alberta, JA; Ficarro, SB; Griveau, A; Sun, Y; Deshpande, JS et al. (Elsevier (Cell Press), 2017-03-28)
    During development of the vertebrate CNS, the basic helix-loop-helix (bHLH) transcription factor Olig2 sustains replication competence of progenitor cells that give rise to neurons and oligodendrocytes. A pathological ...
  • Global reorganisation of $\textit{cis}$-regulatory units upon lineage commitment of human embryonic stem cells 

    Freire-Pritchett, P; Schoenfelder, S; Várnai, C; Wingett, SW; Cairns, J; Collier, AJ; García-Vílchez, R et al. (eLife Sciences Publications Ltd, 2017-03-23)
    Long-range $\textit{cis}$-regulatory elements such as enhancers coordinate cell-specific transcriptional programmes by engaging in DNA looping interactions with target promoters. Deciphering the interplay between the ...

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