Repository logo
 

Total synthesis of jiadifenolide.


Type

Article

Change log

Authors

Xuan, Mengyang 
Dalby, Stephen M 

Abstract

As a potent neurotrophic agent, the sesquiterpenoid jiadifenolide represents a valuable small-molecule lead for the potential therapeutic treatment of neurodegenerative diseases. A stereocontrolled total synthesis of this densely functionalized natural product is reported, central to which is an adventurous samarium-mediated cyclization reaction to establish the tricyclic core and the adjacent C5 and C6 quaternary stereocenters.

Description

Keywords

cyclization, neurological agents, samarium, terpenoids, total synthesis, Crystallography, X-Ray, Cyclization, Molecular Structure, Oxidation-Reduction, Sesquiterpenes, Stereoisomerism, Vinyl Compounds

Journal Title

Angew Chem Int Ed Engl

Conference Name

Journal ISSN

1433-7851
1521-3773

Volume Title

53

Publisher

Wiley
Sponsorship
We thank Clare College Cambridge (Fellowship to S.M.D.) and the EPSRC UK National Mass Spectrometry Facility at Swansea.