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dc.contributor.authorPaterson, Ianen
dc.contributor.authorXuan, Mengyangen
dc.contributor.authorDalby, Stephen Men
dc.date.accessioned2014-10-16T10:33:27Z
dc.date.available2014-10-16T10:33:27Z
dc.date.issued2014-05-23en
dc.identifier.citationAngewandte Chemie 53: 7286–7289. DOI: 10.1002/anie.201404224en
dc.identifier.issn1433-7851
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/246182
dc.description.abstractAs a potent neurotrophic agent, the sesquiterpenoid jiadifenolide represents a valuable small-molecule lead for the potential therapeutic treatment of neurodegenerative diseases. A stereocontrolled total synthesis of this densely functionalized natural product is reported, central to which is an adventurous samarium-mediated cyclization reaction to establish the tricyclic core and the adjacent C5 and C6 quaternary stereocenters.
dc.description.sponsorshipWe thank Clare College Cambridge (Fellowship to S.M.D.) and the EPSRC UK National Mass Spectrometry Facility at Swansea.
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.subjectcyclizationen
dc.subjectneurological agentsen
dc.subjectsamariumen
dc.subjectterpenoidsen
dc.subjecttotal synthesisen
dc.titleTotal Synthesis of Jiadifenolideen
dc.typeArticle
dc.description.versionThis is the final published version. It's also available from Wiley at http://onlinelibrary.wiley.com/doi/10.1002/anie.201404224/abstract.en
prism.endingPage7289
prism.publicationDate2014en
prism.publicationNameAngewandte Chemie International Editionen
prism.startingPage7286
prism.volume53en
dc.rioxxterms.funderEPSRC
rioxxterms.versionofrecord10.1002/anie.201404224en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-05-23en
dc.contributor.orcidPaterson, Ian [0000-0002-8861-9136]
dc.identifier.eissn1521-3773
rioxxterms.typeJournal Article/Reviewen


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales