A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences
Ingham, Richard J
Hawkins, Joel M
Angewandte Chemie International Edition
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Ingham, R. J., Battilocchio, C., Fitzpatrick, D., Sliwinski, E., Hawkins, J. M., & Ley, S. (2014). A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences. Angewandte Chemie International Edition, 54 144-148. https://doi.org/10.1002/anie.201409356
Performing reactions in flow can offer major advantages over batch methods. However, laboratory flow chemistry processes are currently often limited to single steps or short sequences due to the complexity involved with operating a multi-step process. Using new modular components for downstream processing, coupled with control technologies, more advanced multi-step flow sequences can be realized. Here, we report the application of these tools to the synthesis of 2-aminoadamantane-2- carboxylic acid. A system comprising three chemistry steps and three workup steps was developed, having sufficient autonomy and selfregulation to be managed by a single operator.
The authors gratefully acknowledge support from Ralph Raphael Scholarship (RJI), Woolf Fisher Trust (DEF), UK Engineering and Physical Sciences Research Council (ES and SVL) and Pfizer Worldwide Research and Development (CB and JMH).
External DOI: https://doi.org/10.1002/anie.201409356
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246205
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/