Repository logo
 

A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences.


Change log

Authors

Ingham, Richard J 
Battilocchio, Claudio  ORCID logo  https://orcid.org/0000-0002-4601-8527
Fitzpatrick, Daniel E 
Sliwinski, Eric 
Hawkins, Joel M 

Abstract

Performing reactions in flow can offer major advantages over batch methods. However, laboratory flow chemistry processes are currently often limited to single steps or short sequences due to the complexity involved with operating a multi-step process. Using new modular components for downstream processing, coupled with control technologies, more advanced multi-step flow sequences can be realized. These tools are applied to the synthesis of 2-aminoadamantane-2-carboxylic acid. A system comprising three chemistry steps and three workup steps was developed, having sufficient autonomy and self-regulation to be managed by a single operator.

Description

Keywords

continuous processing, flow reactors, integrated systems, synthetic methods, Amantadine, Carboxylic Acids, Chemistry Techniques, Synthetic, Equipment Design

Journal Title

Angew Chem Int Ed Engl

Conference Name

Journal ISSN

1433-7851
1521-3773

Volume Title

54

Publisher

Wiley
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
The authors gratefully acknowledge support from Ralph Raphael Scholarship (RJI), Woolf Fisher Trust (DEF), UK Engineering and Physical Sciences Research Council (ES and SVL) and Pfizer Worldwide Research and Development (CB and JMH).