Gut Chemosensing Mechanisms
Journal of Clinical Investigation
American Society for Clinical Investigation
MetadataShow full item record
Psichas, A., Reimann, F., & Gribble, F. (2015). Gut Chemosensing Mechanisms. Journal of Clinical Investigation, 125 908-917. https://doi.org/10.1172/JCI76309
The enteroendocrine system is the primary sensor of ingested nutrients and is responsible for secreting an array of gut hormones, which modulate multiple physiological responses including gastrointestinal motility and secretion, glucose homeostasis and appetite. This review provides an up-to-date synopsis of the molecular mechanisms underlying enteroendocrine nutrient sensing and highlights our current understanding of the neuro-hormonal regulation of gut hormone secretion, including the interaction between the enteroendocrine system and the enteric nervous system. It is hoped that a deeper understanding of how these systems collectively regulate postprandial physiology could further facilitate the development of novel therapeutic strategies.
Research in the Reimann and Gribble laboratories is currently funded by the Wellcome trust (084210/Z/07/Z and 088357/Z/09/Z), Full4Health (FP7/2011-2015, grant agreement no. 266408) and the MRC (MRC_MC_UU_12012/3).
Wellcome Trust (084210/Z/07/Z)
Wellcome Trust (088357/Z/09/Z)
External DOI: https://doi.org/10.1172/JCI76309
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246219