Exploring phosphatidylinositol 5-phosphate 4-kinase function.
Change log
Authors
Bulley, Simon J
Clarke, Jonathan H
Droubi, Alaa
Giudici, Maria-Luisa
Irvine, Robin F
Abstract
The family of phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) is emerging from a comparative backwater in inositide signalling into the mainstream, as is their substrate, phosphatidylinositol 5-phosphate (PI5P). Here we review some of the key questions about the PI5P4Ks, their localisation, interaction, and regulation and also we summarise our current understanding of how PI5P is synthesised and what its cellular functions might be. Finally, some of the evidence for the involvement of PI5P4Ks in pathology is discussed.
Description
Keywords
Inositide, Kinase, Phosphatidylinositol, Phosphatidylinositol 5-Phosphate4-kinase, Phosphatidylinositol 5-phosphate, Animals, Humans, Phosphatidylinositol Phosphates, Phosphotransferases (Alcohol Group Acceptor), Signal Transduction
Journal Title
Adv Biol Regul
Conference Name
Journal ISSN
2212-4926
2212-4934
2212-4934
Volume Title
57
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/J01575X/1)
Medical Research Council (MR/J001120/1)
Medical Research Council (MR/J001120/1)