Introductory lecture: Mechanochemistry, a versatile synthesis strategy for new materials.
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Publication Date
2014Journal Title
Faraday Discuss
ISSN
1359-6640
Publisher
Royal Society of Chemistry (RSC)
Volume
170
Pages
9-34
Language
English
Type
Article
Metadata
Show full item recordCitation
Jones, B., & Eddleston, M. (2014). Introductory lecture: Mechanochemistry, a versatile synthesis strategy for new materials.. Faraday Discuss, 170 9-34. https://doi.org/10.1039/c4fd00162a
Abstract
Mechanochemistry deals with reactions induced by the input of mechanical energy - for example by impacts within a vibratory ball mill. The technique has a long history with significant contributions from Ostwald, Carey Lea and, notably, Faraday. Mechanochemistry has subsequently seen application in a variety of areas of materials science including mechanical alloying in metallurgy, the synthesis of complex organic molecules and, more recently, the discovery and development of new solid forms of active pharmaceutical ingredients. This paper overviews the broad areas of application of mechanochemistry, some key features which make it a particularly attractive approach to materials synthesis and some mechanistic aspects highlighted within the literature. A significant part, however, will focus on recent applications in the area of pharmaceuticals and its important role in exploring the rich variety of solid forms available for small, drug-like, molecules.
Identifiers
External DOI: https://doi.org/10.1039/c4fd00162a
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246232
Rights
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/
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