Sleep duration and cardiometabolic risk factors among individuals with type 2 diabetes
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Cooper, A., Westgate, K., Brage, S., Prevost, A. T., Griffin, S., & Simmons, R. (2014). Sleep duration and cardiometabolic risk factors among individuals with type 2 diabetes. Sleep Medicine, 16 119-125. https://doi.org/10.1016/j.sleep.2014.10.006
Objective: To examine the association between sleep duration and cardiometabolic risk factors among individuals with recently diagnosed type 2 diabetes (n=391). Methods: Sleep duration was derived using a combination of questionnaire and objective heart rate and movement sensing in the UK ADDITION-Plus study (2002-2007). Adjusted means were estimated for individual cardiometabolic risk factors and clustered cardiometabolic risk (CCMR) by five categories of sleep duration. Results: We observed a J-shaped association between sleep duration and CCMR – individuals sleeping 7-<8 hours had a significantly better CCMR profile than those sleeping ≥9 hours. Independent of physical activity and sedentary time, individuals sleeping 7-<8 hours had lower triacylglycerol (0.62 mmol/l [0.29, 1.06]) and higher HDL-cholesterol levels (0.23 mmol/l [0.16, 0.30]) compared with those sleeping ≥9 hours, and a lower waist circumference (7.87 cm [6.06, 9.68]) and BMI (3.47 kg/m2 [2.69, 4.25]) than those sleeping <6 hours. Although sleeping 7-<8 hours was associated with lower levels of systolic- and diastolic- blood pressure, HbA1c, total cholesterol and LDL-cholesterol, these associations were not statistically significant. Conclusions: Sleep duration has a J-shaped association with CCMR in individuals with diabetes, independent of potential confounding. Health promotion interventions might highlight the importance of adequate sleep in this high risk population.
sleep duration, type 2 diabetes, cardiovascular risk, waist circumference, lipids, BMI
The trial is supported by the Wellcome Trust, the Medical Research Council, Diabetes UK and National Health Service R&D support funding. SJG was a member of the National Institute for Health Research (NIHR) School for Primary Care Research. The General Practice and Primary Care Research Unit was supported by NIHR Research funds. SJG received support from the Department of Health NIHR Programme Grant funding scheme [RP-PG-0606-1259]. ATP is supported by the NIHR Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London.
Wellcome Trust (061895/Z/00/Z)
Medical Research Council (MC_U106179474)
NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC) (HTA/08/116/300)
NIHR Central Commissioning Facility (NIHRDH-RP-PG-0606-1259)
External DOI: https://doi.org/10.1016/j.sleep.2014.10.006
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246252