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dc.contributor.authorKhandaker, Golamen
dc.contributor.authorCousins, Lesleyen
dc.contributor.authorDeakin, Juliaen
dc.contributor.authorLennox, Belinda Ren
dc.contributor.authorYolken, Roberten
dc.contributor.authorJones, Peteren
dc.date.accessioned2014-11-05T15:54:21Z
dc.date.available2014-11-05T15:54:21Z
dc.date.issued2014-12-09en
dc.identifier.citationThe Lancet Psychiatry Volume 2, No. 3, p258–270, March 2015. DOI: http://dx.doi.org/10.1016/S2215-0366(14)00122-9en
dc.identifier.issn2215-0366
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/246288
dc.description.abstractComplex interactions between the immune system and the brain may have important aetiological and therapeutic implications for neuropsychiatric brain disorders. A possible association between schizophrenia and the immune system was postulated over a century ago, and is supported by epidemiological and genetic studies pointing to links with infection and inflammation. Contrary to the traditional view that the brain is an immunologically privileged site shielded behind the blood-brain-barrier, recent studies have demonstrated complex interactions between the immune system, systemic inflammation and the brain that can lead to changes in mood, cognition, and behaviour. Here, we review some of the important areas of research regarding innate and adaptive immune response in schizophrenia and related psychotic disorders that, we think, will be of interest to psychiatric clinicians and researchers. We discuss potential mechanisms and therapeutic implications of these findings including studies of anti-inflammatory agents in schizophrenia, highlight areas for development, and offer testable hypothesis for future investigations.
dc.description.sponsorshipThe work was supported by a doctoral clinical research training fellowship grant from the Wellcome Trust to Golam Khandaker (094790/Z/10/Z; 2010-‘13), grants from the Stanley Medical Research Institute and the National Institutes of Mental Health (grant# MH-94268) to Robert Yolken, and grants from the Wellcome Trust (095844/Z/11/Z & 088869/Z/09/Z), and the NIHR (RP-PG-0606-1335) to Peter Jones.
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.subjectInflammationen
dc.subjectinfectionen
dc.subjectimmunityen
dc.subjectautoimmunityen
dc.subjectinflammatory markersen
dc.subjectC-reactive proteinen
dc.subjectCRPen
dc.subjectInterleukin 6en
dc.subjectIL-6en
dc.subjectantibodyen
dc.subjectNMDA receptoren
dc.subjectcytokineen
dc.subjectlymphocyteen
dc.subjectmacrophageen
dc.subjectmicrogliaen
dc.subjectmicrobiotaen
dc.subjectinnate immunityen
dc.subjectadaptive immunityen
dc.subjectdopamineen
dc.subjectglutamateen
dc.subjectneurodevelopmenten
dc.subjectneurodegenerationen
dc.subjectschizophreniaen
dc.subjectpsychotic disordersen
dc.subjecttreatmenten
dc.subjectanti-inflammatory agenten
dc.subjectimmuno-psychiatryen
dc.titleInflammation and immunity in schizophrenia: implications for pathophysiology and treatmenten
dc.typeArticle
dc.description.versionThis is the accepted manuscript. The final version is available from Elsevier at http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366%2814%2900122-9/abstracten
prism.endingPage270
prism.publicationDate2014en
prism.publicationNameThe Lancet Psychiatryen
prism.startingPage258
prism.volume2en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderNIHR
dc.rioxxterms.projectid094790/Z/10/Z
dc.rioxxterms.projectid095844/Z/11/Z
dc.rioxxterms.projectid088869/Z/09/Z
dcterms.dateAccepted2014-10-03en
rioxxterms.versionofrecord10.1016/S2215-0366(14)00122-9en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-12-09en
dc.contributor.orcidKhandaker, Golam [0000-0002-4935-9220]
dc.contributor.orcidJones, Peter [0000-0002-0387-880X]
dc.identifier.eissn2215-0374
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (088869/Z/09/Z)
pubs.funder-project-idWellcome Trust (094790/Z/10/Z)
pubs.funder-project-idWellcome Trust (095844/Z/11/Z)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/J012939/1)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)


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