Comparative Cytotoxicity of Artemisinin and Cisplatin and Their Interactions with Chlorogenic Acids in MCF7 Breast Cancer Cells
Barker, Guy C
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Suberu, J., Romero-Canelón, I., Sullivan, N., Lapkin, A., & Barker, G. C. (2014). Comparative Cytotoxicity of Artemisinin and Cisplatin and Their Interactions with Chlorogenic Acids in MCF7 Breast Cancer Cells. ChemMedChem, 9 2791-2797. https://doi.org/10.1002/cmdc.201402285
In parts of Africa and Asia, self-medication with a hot water infusion of Artemisia annua (Artemisia tea) is a common practice for a number of ailments including malaria and cancer. In our earlier work, such an extract showed better potency than artemisinin alone against both chloroquine-sensitive and -resistant parasites. In this study, in vitro tests of the infusion in MCF7 cells showed high IC50 values (>200 μM). The combination of artemisinin and 3-caffeoylquinic acid (3CA), two major components in the extract, was strongly antagonistic and gave a near total loss of cytotoxicity for artemisinin. We observed that the interaction of 3CAs with another cytotoxic compound, cisplatin, showed potentiation of activity by 2.5-fold. The chelation of cellular iron by 3CA is hypothesized as a possible explanation for the loss of artemisinin activity.
antagonism, Artemisia tea, artemisinin, chlorogenic acid, cisplatin, synergy
This study was funded by the Engineering and Physical Sciences Research Council (EPSRC, UK) and SensaPharm Ltd. via an Industrial CASE PhD studentship. The award was allocated competitively by the Chemistry Innovation Knowledge Transfer Network (CIKTN, UK).
External DOI: https://doi.org/10.1002/cmdc.201402285
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246303
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/
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