Brain glucose sensing, glucokinase and neural control of metabolism and islet function
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Ogunnowo-Bada, E., Heeley, N., Brochard, L., & Evans, M. (2014). Brain glucose sensing, glucokinase and neural control of metabolism and islet function. 16 26-32. https://doi.org/10.1111/dom.12334
It is increasingly apparent that brain plays a central role in metabolic homeostasis including the maintenance of blood glucose. This is achieved by various efferent pathways from brain to periphery, which help control hepatic glucose flux and perhaps insulin stimulated insulin secretion. Also, critically important for brain given its dependence on a constant supply of glucose as a fuel, emergency counter regulatory responses are triggered by brain if blood glucose starts to fall. To exert these control functions, brain needs to detect rapidly and accurately changes in blood glucose. In this review, we summarise some of the mechanisms postulated to play a role in this and examine the potential role of the low affinity hexokinase, glucokinase, in brain as a key part of some of this sensing. We also discuss how these processes may become altered in diabetes and related metabolic disease.
Glucokinase, hypoglycaemia, hypothalamus, glucose-sensing, insulin, glucosestimulated insulin secretion
Funding and support from Wellcome Trust, Medical Research Council including the Cambridge MRC Centre for Study of Obesity and Related Disorders (MRC-CORD), NIHR Cambridge Biomedical Research Centre, Diabetes UK (RD05/003059) and Yousef Jameel Fund).
Medical Research Council (MC_UU_12012/5/B)
Wellcome Trust (100574/Z/12/Z)
External DOI: https://doi.org/10.1111/dom.12334
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246306
Attribution 2.0 UK: England & Wales, Creative Commons Attribution License 2.0 UK
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/