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dc.contributor.authorAbenza Martinez, Juanen
dc.contributor.authorChessel, Anatoleen
dc.contributor.authorRaynaud, William Gen
dc.contributor.authorCarazo Salas, Rafaelen
dc.date.accessioned2014-11-11T17:12:05Z
dc.date.available2014-11-11T17:12:05Z
dc.date.issued2014-09-11en
dc.identifier.citationPLoS ONE 9(9): e106959en
dc.identifier.issn1932-6203
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/246337
dc.description.abstractEvery cell has a characteristic shape key to its fate and function. That shape is not only the product of genetic design and of the physical and biochemical environment, but it is also subject to inheritance. However, the nature and contribution of cell shape inheritance to morphogenetic control is mostly ignored. Here, we investigate morphogenetic inheritance in the cylindrically-shaped fission yeast Schizosaccharomyces pombe. Focusing on sixteen different ‘curved’ mutants - a class of mutants which often fail to grow axially straight – we quantitatively characterize their dynamics of cell shape inheritance throughout generations. We show that mutants of similar machineries display similar dynamics of cell shape inheritance, and exploit this feature to show that persistent axial cell growth in S. pombe is secured by multiple, separable molecular pathways. Finally, we find that one of those pathways corresponds to the swc2-swr1-vps71 SWR1/SRCAP chromatin remodelling complex, which acts additively to the known mal3-tip1-mto1-mto2 microtubule and tea1-tea2-tea4-pom1 polarity machineries.
dc.languageen_USen
dc.language.isoen_USen
dc.publisherPLoS
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.titleDynamics of Cell Shape Inheritance in Fission Yeasten
dc.typeArticle
dc.description.versionThis is the published manuscript. It has been published by PLoS in PLoS ONE and is available online here: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0106959.en
prism.publicationDate2014en
prism.publicationNamePLoS ONEen
prism.startingPagee106959
prism.volume9en
dc.rioxxterms.funderEuropean Research Council; Ramón Areces Foundation Postdoctoral Fellowship; Herchel Smith Postdoctoral Fellowship; Human Frontier Science Program; Biological Sciences Research Council
dc.rioxxterms.projectidERC: SYSGRO; HFSP: RGY0066/2009-C; BBSRC: BB/K006320/1
dcterms.dateAccepted2014-08-01en
rioxxterms.versionofrecord10.1371/journal.pone.0106959en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-09-11en
dc.identifier.eissn1932-6203
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/K006320/1)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales