Influenza A/H7N9 virus emergence in poultry and humans in Guangdong China
Fouchier, Ron AM
Emerging Infectious Diseases
Centers for Disease Control and Prevention
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Ke, C., Lu, J., Wu, J., Guan, D., Zou, L., Song, T., Yi, L., et al. (2014). Influenza A/H7N9 virus emergence in poultry and humans in Guangdong China. Emerging Infectious Diseases, 20 https://doi.org/10.3201/eid2012.140765
Background Influenza A/H7N9 virus emerged in eastern China February 2013, and continues to circulate but ecology is poorly understood. Methods In March 2013, Guangdong Centers for Disease Control (CDC) implemented environmental- and human syndromic surveillance. Environmental samples from poultry markets in 21 city CDC’s (n= 8,942), and respiratory samples from individuals with influenza like illness or pneumonia (n= 32,342) were tested by RT-PCR. Viruses isolated from 16 patients and 6 environmental samples were sequenced. Results A steep increase in human cases was observed starting November 2013, coinciding with emergence of influenza A/H7 virus in environmental surveillance. Sequence analysis showed co-circulation of 4 reassortant viruses that evolved from the original virus by reassortment with local avian influenza A/H9N2 viruses. Conclusion: The steep increase in notifications of human cases in Guangdong late 2013 was caused by new, locally acquired reassortant viruses, reflecting widespread undetected local transmission.
This study was financially supported by 12th five-year-major-projects of China’s Ministry of Public Health. Grant No: 2012zx10004-213 and by the PREDICT Surveillance Animal Human Interface Project of GVF. Grant No: Gvf: 06-09-057-02.
External DOI: https://doi.org/10.3201/eid2012.140765
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246392
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/
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