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dc.contributor.authorKe, Changwenen
dc.contributor.authorLu, Jingen
dc.contributor.authorWu, Jieen
dc.contributor.authorGuan, Daweien
dc.contributor.authorZou, Lirongen
dc.contributor.authorSong, Tieen
dc.contributor.authorYi, Linaen
dc.contributor.authorZeng, Xianqiaoen
dc.contributor.authorLiang, Lijunen
dc.contributor.authorNi, Hanzhongen
dc.contributor.authorKang, Minen
dc.contributor.authorZhang, Xinen
dc.contributor.authorZhong, Haojieen
dc.contributor.authorHe, Jianfengen
dc.contributor.authorLin, Jinyanen
dc.contributor.authorSmith, Dereken
dc.contributor.authorBurke, Daviden
dc.contributor.authorFouchier, Ron AMen
dc.contributor.authorKoopmans, Marionen
dc.contributor.authorZhang, Yonghuien
dc.date.accessioned2014-11-13T15:59:13Z
dc.date.available2014-11-13T15:59:13Z
dc.date.issued2014-08-27en
dc.identifier.citationEmerging Infectious Diseases 2014 Volume 20, Number 12—December 2014 DOI: 10.3201/eid2012.140765en
dc.identifier.issn1080-6040
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/246392
dc.description.abstractBackground Influenza A/H7N9 virus emerged in eastern China February 2013, and continues to circulate but ecology is poorly understood. Methods In March 2013, Guangdong Centers for Disease Control (CDC) implemented environmental- and human syndromic surveillance. Environmental samples from poultry markets in 21 city CDC’s (n= 8,942), and respiratory samples from individuals with influenza like illness or pneumonia (n= 32,342) were tested by RT-PCR. Viruses isolated from 16 patients and 6 environmental samples were sequenced. Results A steep increase in human cases was observed starting November 2013, coinciding with emergence of influenza A/H7 virus in environmental surveillance. Sequence analysis showed co-circulation of 4 reassortant viruses that evolved from the original virus by reassortment with local avian influenza A/H9N2 viruses. Conclusion: The steep increase in notifications of human cases in Guangdong late 2013 was caused by new, locally acquired reassortant viruses, reflecting widespread undetected local transmission.
dc.description.sponsorshipThis study was financially supported by 12th five-year-major-projects of China’s Ministry of Public Health. Grant No: 2012zx10004-213 and by the PREDICT Surveillance Animal Human Interface Project of GVF. Grant No: Gvf: 06-09-057-02.
dc.languageEnglishen
dc.language.isoenen
dc.publisherCenters for Disease Control and Prevention
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.titleInfluenza A/H7N9 virus emergence in poultry and humans in Guangdong Chinaen
dc.typeArticle
dc.description.versionThis is the accepted version. It'll be replaced with the final pdf when it's available.en
prism.publicationDate2014en
prism.publicationNameEmerging Infectious Diseasesen
prism.volume20en
dc.rioxxterms.funderChina’s Ministry of Public Health
dc.rioxxterms.funderGVF
dc.rioxxterms.projectid2012zx10004-213
dc.rioxxterms.projectidGvf: 06-09-057-02
rioxxterms.versionofrecord10.3201/eid2012.140765en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-08-27en
dc.contributor.orcidSmith, Derek [0000-0002-2393-1890]
dc.contributor.orcidBurke, David [0000-0001-8830-3951]
dc.identifier.eissn1080-6059
rioxxterms.typeJournal Article/Reviewen


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales