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dc.contributor.authorGlöckner, Steffenen
dc.contributor.authorTran, Duc Nen
dc.contributor.authorIngham, Richard Jen
dc.contributor.authorFenner, Sabineen
dc.contributor.authorWilson, Zoeen
dc.contributor.authorBattilocchio, Claudioen
dc.contributor.authorLey, Steven Victoren
dc.date.accessioned2014-11-18T16:50:42Z
dc.date.available2014-11-18T16:50:42Z
dc.date.issued2014-10-28en
dc.identifier.citationOrganic & Biomolecular Chemistry 2015,13, 207-214. DOI: 10.1039/C4OB02105Cen
dc.identifier.issn1477-0520
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/246399
dc.description.abstractA rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereochemistry, from β-hydroxy amides using Deoxo-Fluor®. The corresponding oxazoles can then be obtained via a packed reactor containing commercial manganese dioxide.
dc.description.sponsorshipWe are grateful to the Swiss National Science Foundation (DNT), the Ralph Raphael fellowship (RJI), the German Academic Exchange Service DAAD (SF), the Royal Society Newton International Fellowship (ZEW), Pfizer Worldwide Research and Development (CB) and the EPSRC (SVL, SF and ZEW, grant nº EP/K0099494/1) for financial support. The Labtrix Start was kindly loaned by Chemtrix BV and the liquid-liquid phase separator by Zaiput Flow Technologies (we are grateful to Dr Andrea Adamo for technical support with this device).
dc.languageEnglishen
dc.language.isoenen
dc.publisherRoyal Society of Chemistry
dc.rightsAttribution-NonCommercial 2.0 UK: England & Wales
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.0/uk/
dc.titleThe rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditionsen
dc.typeArticle
dc.description.versionThis is the final version. It was first published by the Royal Society of Chemistry at http://dx.doi.org/10.1039/C4OB02105Cen
prism.endingPage214
prism.publicationDate2014en
prism.publicationNameOrganic & Biomolecular Chemistryen
prism.startingPage207
prism.volume13en
dc.rioxxterms.funderSwiss National Science Foundation
dc.rioxxterms.funderEPSRC
dc.rioxxterms.funderRoyal Society
dc.rioxxterms.projectidEP/K0099494/1
rioxxterms.versionofrecord10.1039/C4OB02105Cen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-10-28en
dc.contributor.orcidWilson, Zoe [0000-0003-4606-9831]
dc.contributor.orcidBattilocchio, Claudio [0000-0002-4601-8527]
dc.contributor.orcidLey, Steven Victor [0000-0002-7816-0042]
dc.identifier.eissn1477-0539
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (EP/K009494/1)


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Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 2.0 UK: England & Wales