Flow Chemistry as a Discovery Tool to Access sp2-sp3 Cross-Coupling Reactions via Diazo Compounds
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Publication Date
2014-11-07Journal Title
Chemical Science
ISSN
2041-6520
Publisher
Royal Society of Chemistry
Volume
6
Pages
1120-1125
Language
English
Type
Article
Metadata
Show full item recordCitation
Tran, D. N., Battilocchio, C., Lou, S., Hawkins, J. M., & Ley, S. (2014). Flow Chemistry as a Discovery Tool to Access sp2-sp3 Cross-Coupling Reactions via Diazo Compounds. Chemical Science, 6 1120-1125. https://doi.org/10.1039/C4SC03072A
Abstract
The work constitutes an interesting aspect of flow chemistry, whereby the generation of a transient species (or reactive intermediate) is followed by a translocation step into another chemical environment, before reacting it with a coupling partner. The concept is successfully applied to achieve a room temperature sp2-sp3 cross coupling of boronic acids with diazo compounds, these latter species being generated from hydrazones under flow conditions using MnO2 as the oxidant.
Sponsorship
We are grateful to the Swiss National Science Foundation (DNT), Pfizer Worldwide Research and Development (CB and JMH), and the EPSRC (SVL, grant nº EP/K0099494/1) for financial support.
Funder references
EPSRC (EP/K009494/1)
EPSRC (EP/K039520/1)
Identifiers
External DOI: https://doi.org/10.1039/C4SC03072A
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246400
Rights
Attribution-NonCommercial 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by-nc/2.0/uk/
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