Flow Chemistry as a Discovery Tool to Access sp2-sp3 Cross-Coupling Reactions via Diazo Compounds
Royal Society of Chemistry
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Tran, D. N., Battilocchio, C., Lou, S., Hawkins, J. M., & Ley, S. (2014). Flow Chemistry as a Discovery Tool to Access sp2-sp3 Cross-Coupling Reactions via Diazo Compounds. Chemical Science, 6 1120-1125. https://doi.org/10.1039/C4SC03072A
The work constitutes an interesting aspect of flow chemistry, whereby the generation of a transient species (or reactive intermediate) is followed by a translocation step into another chemical environment, before reacting it with a coupling partner. The concept is successfully applied to achieve a room temperature sp2-sp3 cross coupling of boronic acids with diazo compounds, these latter species being generated from hydrazones under flow conditions using MnO2 as the oxidant.
We are grateful to the Swiss National Science Foundation (DNT), Pfizer Worldwide Research and Development (CB and JMH), and the EPSRC (SVL, grant nº EP/K0099494/1) for financial support.
External DOI: https://doi.org/10.1039/C4SC03072A
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246400
Attribution-NonCommercial 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by-nc/2.0/uk/
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