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The role of gut endocrine cells in control of metabolism and appetite.


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Authors

Parker, Helen E 
Gribble, Fiona M 

Abstract

After food is ingested, nutrients pass through the gastrointestinal tract, stimulating the release of a range of peptide hormones. Among their many local, central and peripheral actions, these hormones act to mediate glucose metabolism and satiety. Indeed, it is the modification of gut hormone secretion that is considered partly responsible for the normalization of glycaemic control and the reduction in appetite seen in many patients after certain forms of bariatric surgery. This review describes recent developments in our understanding of the secretion and action of anorexigenic gut hormones, primarily concentrating on glucagon-like peptide-1 (GLP-1).

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Keywords

Animals, Appetite Regulation, Brain, Eating, Energy Metabolism, Enteroendocrine Cells, Feeding Behavior, Gastrointestinal Tract, Glucagon-Like Peptide 1, Humans, Neural Pathways, Obesity, Signal Transduction

Journal Title

Exp Physiol

Conference Name

Journal ISSN

0958-0670
1469-445X

Volume Title

99

Publisher

Wiley
Sponsorship
Medical Research Council (MC_UU_12012/3)
Wellcome Trust (088357/Z/09/A)
Medical Research Council (MC_PC_12012)